Romycin
Generic Name
Erythromycin
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| romycin 200 mg suspension | ৳ 90.00 | N/A |
Description
Overview of the medicine
Romycin 200 mg Suspension contains Erythromycin, a macrolide antibiotic, used to treat a wide range of bacterial infections including respiratory tract infections, skin and soft tissue infections, and certain sexually transmitted infections.
Uses & Indications
Dosage
Adults
Typical dose: 250-500 mg (approx. 6.25-12.5 mL of 200mg/5mL suspension) orally every 6-12 hours, depending on the severity of the infection. For specific infections, dosage may vary.
Elderly
No specific dose adjustment is usually required for elderly patients, but caution should be exercised in those with hepatic impairment.
Renal_impairment
No dosage adjustment is generally necessary for patients with renal impairment, but monitoring is advised for severe cases.
How to Take
Take orally, preferably on an empty stomach (1 hour before or 2 hours after meals) for optimal absorption of the base, though food may be taken with the ethylsuccinate form to reduce gastrointestinal upset. Shake the suspension well before each use.
Mechanism of Action
Erythromycin works by inhibiting bacterial protein synthesis. It binds reversibly to the 50S ribosomal subunit of susceptible bacteria, thus blocking the translocation reaction and preventing the growth and multiplication of bacteria.
Pharmacokinetics
Onset
Peak plasma concentrations usually occur within 1-4 hours after oral administration.
Excretion
Mainly excreted in the bile and feces; a small amount is excreted in the urine.
Half life
Approximately 1.5 to 2 hours in adults with normal renal function.
Absorption
Well absorbed orally, but absorption of the base form is reduced by food. Esters (e.g., stearate, ethylsuccinate) have better absorption characteristics.
Metabolism
Primarily metabolized in the liver by the cytochrome P450 3A4 (CYP3A4) enzyme system.
Side Effects
Contraindications
- Hypersensitivity to Erythromycin or any macrolide antibiotic
- Concomitant use with terfenadine, astemizole, cisapride, pimozide, or ergot alkaloids (e.g., ergotamine, dihydroergotamine) due to risk of serious cardiovascular events
Drug Interactions
Digoxin
Increased serum digoxin levels.
Statins
Increased risk of myopathy and rhabdomyolysis.
Warfarin
Potentiates anticoagulant effect, increasing risk of bleeding.
CYP3A4 Inhibitors
Erythromycin is a potent CYP3A4 inhibitor, increasing levels of drugs metabolized by this enzyme (e.g., statins, warfarin, carbamazepine, ciclosporin).
Antiarrhythmics (e.g., quinidine, disopyramide)
Increased risk of QT prolongation and ventricular arrhythmias.
Storage
Store unreconstituted powder below 30°C, protected from light and moisture. Once reconstituted, store the suspension in a refrigerator (2-8°C) and discard any unused portion after 14 days. Do not freeze.
Overdose
Symptoms of overdose include severe gastrointestinal upset (nausea, vomiting, abdominal pain), reversible hearing loss, and abnormal liver function. Management involves gastric lavage and supportive care. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Erythromycin is generally considered safe for use during pregnancy. It is excreted in breast milk; however, it is generally considered safe for nursing infants, but caution is advised.
Side Effects
Contraindications
- Hypersensitivity to Erythromycin or any macrolide antibiotic
- Concomitant use with terfenadine, astemizole, cisapride, pimozide, or ergot alkaloids (e.g., ergotamine, dihydroergotamine) due to risk of serious cardiovascular events
Drug Interactions
Digoxin
Increased serum digoxin levels.
Statins
Increased risk of myopathy and rhabdomyolysis.
Warfarin
Potentiates anticoagulant effect, increasing risk of bleeding.
CYP3A4 Inhibitors
Erythromycin is a potent CYP3A4 inhibitor, increasing levels of drugs metabolized by this enzyme (e.g., statins, warfarin, carbamazepine, ciclosporin).
Antiarrhythmics (e.g., quinidine, disopyramide)
Increased risk of QT prolongation and ventricular arrhythmias.
Storage
Store unreconstituted powder below 30°C, protected from light and moisture. Once reconstituted, store the suspension in a refrigerator (2-8°C) and discard any unused portion after 14 days. Do not freeze.
Overdose
Symptoms of overdose include severe gastrointestinal upset (nausea, vomiting, abdominal pain), reversible hearing loss, and abnormal liver function. Management involves gastric lavage and supportive care. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Erythromycin is generally considered safe for use during pregnancy. It is excreted in breast milk; however, it is generally considered safe for nursing infants, but caution is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unreconstituted powder: 2-3 years. Reconstituted suspension: up to 14 days when stored refrigerated (2-8°C).
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Erythromycin has been extensively studied since its discovery and is a well-established antibiotic with numerous clinical trials supporting its efficacy and safety in various bacterial infections.
Lab Monitoring
- Liver function tests (LFTs) if treatment is prolonged or in patients with pre-existing hepatic impairment
- Renal function tests in patients with severe renal impairment
- Culture and sensitivity testing to confirm pathogen susceptibility
Doctor Notes
- Emphasize the importance of completing the full course of treatment to minimize resistance development.
- Counsel patients on potential drug interactions, especially with CYP3A4 substrates and QT-prolonging agents.
- Advise patients to report severe or persistent diarrhea, which may indicate C. difficile infection.
Patient Guidelines
- Complete the full course of antibiotics, even if symptoms improve, to prevent resistance and recurrence.
- Do not share this medicine with others, even if they have similar symptoms.
- Report any severe or persistent side effects to your doctor.
- Shake the suspension bottle well before each use.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness or visual disturbances in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hydration, especially if experiencing diarrhea or vomiting.
- Avoid alcohol consumption, especially if experiencing gastrointestinal upset.
- Follow a balanced diet.
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