Rosela
Generic Name
Rosuvastatin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rosela 10 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Rosuvastatin is a statin medication used to lower high cholesterol and triglycerides. It reduces the risk of cardiovascular diseases like heart attack and stroke.
Uses & Indications
Dosage
Adults
Initial dose is usually 5-10 mg once daily, adjusted based on lipid levels and patient response. Maximum dose is 40 mg once daily.
Elderly
No specific dose adjustment is needed based solely on age, but a starting dose of 5 mg is recommended for patients over 70 years due to potential predisposition to myopathy.
Renal_impairment
For patients with severe renal impairment (CrCl <30 mL/min) not on hemodialysis, the recommended starting dose is 5 mg once daily, with a maximum dose of 10 mg once daily. The 40 mg dose is contraindicated in severe renal impairment.
How to Take
Take orally, with or without food, at any time of day. It is generally recommended to take it at the same time each day.
Mechanism of Action
Rosuvastatin selectively inhibits HMG-CoA reductase, an enzyme found in the liver that plays a key role in the production of cholesterol. This leads to a decrease in LDL cholesterol synthesis and an increase in LDL receptor expression on liver cells, enhancing the uptake and catabolism of LDL-C.
Pharmacokinetics
Onset
Lipid-lowering effects typically appear within 1 week of starting therapy, with maximal effect usually achieved within 2-4 weeks.
Excretion
Approximately 90% of the dose is excreted unchanged in the feces, with the remaining part excreted via urine.
Half life
The plasma elimination half-life is approximately 19 hours.
Absorption
Peak plasma concentrations are achieved approximately 3-5 hours after oral administration. Absolute bioavailability is approximately 20%.
Metabolism
Rosuvastatin undergoes limited metabolism, primarily by CYP2C9 (approximately 10%). The primary metabolite, N-desmethyl rosuvastatin, is less active.
Side Effects
Contraindications
- •Active liver disease or unexplained persistent elevations of serum transaminases.
- •Pregnancy and lactation.
- •Severe renal impairment (CrCl <30 mL/min) for the 40 mg dose.
- •Concomitant use with cyclosporine.
- •Hypersensitivity to rosuvastatin or any component of the formulation.
Drug Interactions
Niacin
Increased risk of muscle-related adverse reactions.
Gemfibrozil
Increases rosuvastatin exposure; avoid co-administration if possible, or limit rosuvastatin to 10 mg daily.
Cyclosporine
Concomitant use is contraindicated due to significantly increased rosuvastatin exposure.
Erythromycin
Decreases rosuvastatin exposure.
Warfarin and other coumarin anticoagulants
May increase INR; monitor INR closely upon initiation, dose change, or discontinuation of rosuvastatin.
Protease inhibitors (e.g., Atazanavir/Ritonavir, Lopinavir/Ritonavir)
Significantly increase rosuvastatin exposure; specific dose limitations apply.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
There is no specific antidote for rosuvastatin overdose. In the event of an overdose, treatment should be symptomatic and supportive, and liver function and CK levels should be monitored.
Pregnancy & Lactation
Rosuvastatin is contraindicated during pregnancy and lactation. Women of childbearing potential should use adequate contraception during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture, depending on the manufacturer and specific formulation.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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