Rotarac
Generic Name
Omeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rotarac 009 eye drop | ৳ 110.00 | N/A |
Description
Overview of the medicine
Rotarac (Omeprazole) is a proton pump inhibitor that reduces stomach acid production. It is used to treat conditions like heartburn, ulcers, and GERD.
Uses & Indications
Dosage
Adults
GERD: 20 mg once daily for 4-8 weeks. Duodenal Ulcer: 20 mg once daily for 2-4 weeks. Gastric Ulcer: 20 mg once daily for 4-8 weeks. Zollinger-Ellison Syndrome: Initial dose 60 mg once daily, adjusted based on response.
Elderly
No dosage adjustment generally required, but caution in patients with hepatic impairment.
Renal_impairment
No dosage adjustment required.
How to Take
Take whole capsule with a glass of water, preferably in the morning before a meal. Do not chew or crush the capsule.
Mechanism of Action
Omeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase (proton pump) in the parietal cells of the stomach, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily excreted in the urine (approx. 77%) and feces (approx. 18%).
Half life
0.5-1 hour
Absorption
Rapidly absorbed from the small intestine, but absorption may be affected by food. Bioavailability is about 30-40% for oral dose, increasing with repeated dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system, mainly by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any component of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Digoxin
Increased digoxin levels
Warfarin
Increased INR/bleeding risk
Clopidogrel
Reduced antiplatelet effect of clopidogrel
Methotrexate
Increased methotrexate levels
HIV protease inhibitors (e.g., Atazanavir, Nelfinavir)
Reduced absorption, potential loss of efficacy
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture.
Overdose
Symptoms include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs the potential risk to the fetus. Excreted in breast milk, use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any component of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Digoxin
Increased digoxin levels
Warfarin
Increased INR/bleeding risk
Clopidogrel
Reduced antiplatelet effect of clopidogrel
Methotrexate
Increased methotrexate levels
HIV protease inhibitors (e.g., Atazanavir, Nelfinavir)
Reduced absorption, potential loss of efficacy
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture.
Overdose
Symptoms include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs the potential risk to the fetus. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of omeprazole for various acid-related disorders.
Lab Monitoring
- Consider monitoring magnesium levels with prolonged use, especially with diuretics.
Doctor Notes
- Consider dose reduction for elderly patients or those with severe hepatic impairment.
- Educate patients on potential long-term risks.
- Assess for H. pylori infection in ulcer patients.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or visual disturbances; use caution when driving or operating machinery.
Lifestyle Advice
- Avoid fatty foods, spicy foods, caffeine, and alcohol to reduce reflux symptoms.
- Maintain a healthy weight.
- Avoid lying down immediately after meals.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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