Roxiquin
Generic Name
Roxithromycin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| roxiquin 200 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Roxiquin is a macrolide antibiotic used to treat various bacterial infections including respiratory tract infections, skin and soft tissue infections, and certain genitourinary infections.
Uses & Indications
Dosage
Adults
For adults, the usual dosage is 150 mg twice daily or 300 mg once daily, taken before meals. Treatment duration typically ranges from 5 to 10 days, depending on the infection.
Elderly
No specific dose adjustment is generally required for elderly patients, unless there is severe renal or hepatic impairment.
Renal_impairment
No dose adjustment is needed for mild to moderate renal impairment. Caution is advised in severe renal impairment; a reduced dose may be considered.
How to Take
Roxiquin tablets should be taken orally, preferably before meals (at least 15 minutes before food) with a glass of water, to optimize absorption.
Mechanism of Action
Roxithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thus preventing the growth and multiplication of susceptible bacteria.
Pharmacokinetics
Onset
Peak plasma concentrations are usually reached within 1-2 hours after administration.
Excretion
Primarily excreted via bile and feces (about 50%), with a small amount (less than 10%) excreted in urine.
Half life
The elimination half-life is approximately 10-12 hours.
Absorption
Well absorbed orally, but absorption may be decreased by food. Bioavailability is approximately 50%.
Metabolism
Partially metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to roxithromycin, other macrolides, or any excipients of the product.
- Co-administration with ergot alkaloids (e.g., ergotamine, dihydroergotamine) due to risk of severe vasoconstriction.
- Co-administration with cisapride, pimozide, or terfenadine.
- Severe hepatic impairment.
Drug Interactions
Digoxin
May increase plasma concentrations of digoxin, necessitating monitoring of digoxin levels.
Warfarin
May potentiate the anticoagulant effect of warfarin, requiring INR monitoring and dose adjustment.
Midazolam
May enhance the effects of midazolam and other benzodiazepines.
Theophylline
May increase theophylline levels, requiring therapeutic drug monitoring.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and general supportive measures may be helpful. There is no specific antidote.
Pregnancy & Lactation
Pregnancy: Use Roxiquin during pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Consult a doctor. Lactation: Roxithromycin is excreted in breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to roxithromycin, other macrolides, or any excipients of the product.
- Co-administration with ergot alkaloids (e.g., ergotamine, dihydroergotamine) due to risk of severe vasoconstriction.
- Co-administration with cisapride, pimozide, or terfenadine.
- Severe hepatic impairment.
Drug Interactions
Digoxin
May increase plasma concentrations of digoxin, necessitating monitoring of digoxin levels.
Warfarin
May potentiate the anticoagulant effect of warfarin, requiring INR monitoring and dose adjustment.
Midazolam
May enhance the effects of midazolam and other benzodiazepines.
Theophylline
May increase theophylline levels, requiring therapeutic drug monitoring.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and general supportive measures may be helpful. There is no specific antidote.
Pregnancy & Lactation
Pregnancy: Use Roxiquin during pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Consult a doctor. Lactation: Roxithromycin is excreted in breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent expired
Clinical Trials
Roxithromycin has undergone extensive clinical trials demonstrating its efficacy and safety in treating various susceptible bacterial infections across different patient populations.
Lab Monitoring
- Liver function tests (especially in patients with pre-existing hepatic impairment or during prolonged treatment)
- Renal function tests (in patients with severe renal impairment)
- INR monitoring (for patients on concomitant warfarin)
Doctor Notes
- Emphasize the importance of completing the full prescribed course to prevent bacterial resistance and recurrence of infection.
- Advise patients about potential gastrointestinal side effects and to take the medicine on an empty stomach.
- Monitor liver function tests in patients with pre-existing hepatic impairment or if jaundice/dark urine occurs.
Patient Guidelines
- Always complete the full course of antibiotics, even if symptoms improve, to prevent resistance.
- Do not share this medicine with others, even if they have similar symptoms.
- Report any severe or persistent side effects to your doctor immediately.
- Take the medicine on an empty stomach for better absorption.
Missed Dose Advice
If you miss a dose of Roxiquin, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Roxiquin may cause side effects like dizziness, which could impair your ability to drive or operate machinery. If you experience such effects, avoid these activities.
Lifestyle Advice
- Stay adequately hydrated by drinking plenty of fluids during the treatment period.
- Avoid alcohol consumption while taking Roxiquin as it may exacerbate side effects like nausea or dizziness.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Roxiquin Brand
Other medicines available under the same brand name
