Rubitor
Generic Name
Rosuvastatin
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rubitor 2 mg injection | ৳ 950.00 | N/A |
Description
Overview of the medicine
Rubitor (Rosuvastatin) is a statin medication used to lower high cholesterol and triglycerides, and to prevent cardiovascular diseases such as heart attack and stroke.
Uses & Indications
Dosage
Adults
Usually 5-20 mg orally once daily. Maximum 40 mg daily.
Elderly
No specific dose adjustment is generally required, but consider starting at 5 mg for patients >70 years.
Renal_impairment
Mild to moderate: no dose adjustment. Severe (CrCl <30 mL/min, not on hemodialysis): start with 5 mg once daily, maximum 10 mg once daily.
How to Take
Take orally once daily, with or without food, at any time of day.
Mechanism of Action
Rosuvastatin selectively and competitively inhibits HMG-CoA reductase, an enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis. This leads to a reduction in hepatic cholesterol synthesis and an increase in LDL receptor expression on the liver cell surface, thereby increasing LDL-C uptake and catabolism.
Pharmacokinetics
Onset
Lipid-lowering effects typically begin within 1 week, with maximum effect by 2-4 weeks.
Excretion
Approximately 90% is excreted unchanged in feces, with the remaining 10% excreted in urine.
Half life
Elimination half-life is approximately 19 hours.
Absorption
Peak plasma concentrations are reached approximately 3 to 5 hours after oral administration. Absolute bioavailability is approximately 20%.
Metabolism
Limited metabolism, primarily by CYP2C9. Approximately 10% is metabolized to N-desmethyl rosuvastatin, which has about half the HMG-CoA reductase inhibitory activity.
Side Effects
Contraindications
- Hypersensitivity to rosuvastatin or any component of the formulation
- Active liver disease, including unexplained persistent elevations of serum transaminases
- Pregnancy and lactation
- Severe renal impairment (CrCl <30 mL/min) with concomitant ciclosporin
Drug Interactions
Warfarin
May potentiate anticoagulant effect, requiring INR monitoring.
Ciclosporin
Concomitant use significantly increases rosuvastatin exposure; avoid or use extreme caution.
Gemfibrozil
Increases rosuvastatin exposure; co-administration is not recommended.
Erythromycin
Decreases rosuvastatin exposure.
Oral Contraceptives
May increase plasma concentrations of ethinyl estradiol and norgestrel.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Treatment should be symptomatic and supportive. Monitor liver function and CK levels.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation. Women of childbearing potential should use effective contraception. If pregnancy occurs, discontinue rosuvastatin immediately.
Side Effects
Contraindications
- Hypersensitivity to rosuvastatin or any component of the formulation
- Active liver disease, including unexplained persistent elevations of serum transaminases
- Pregnancy and lactation
- Severe renal impairment (CrCl <30 mL/min) with concomitant ciclosporin
Drug Interactions
Warfarin
May potentiate anticoagulant effect, requiring INR monitoring.
Ciclosporin
Concomitant use significantly increases rosuvastatin exposure; avoid or use extreme caution.
Gemfibrozil
Increases rosuvastatin exposure; co-administration is not recommended.
Erythromycin
Decreases rosuvastatin exposure.
Oral Contraceptives
May increase plasma concentrations of ethinyl estradiol and norgestrel.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Treatment should be symptomatic and supportive. Monitor liver function and CK levels.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation. Women of childbearing potential should use effective contraception. If pregnancy occurs, discontinue rosuvastatin immediately.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities worldwide (e.g., FDA, DGDA)
Patent Status
Generics available (original patent expired)
Clinical Trials
Numerous clinical trials have established rosuvastatin's efficacy in lipid lowering and cardiovascular risk reduction, including JUPITER trial, AURORA trial, etc.
Lab Monitoring
- Liver function tests (ALT, AST) before initiation and as clinically indicated.
- Creatine Kinase (CK) levels if muscle pain or weakness develops.
- Lipid panel (Total-C, LDL-C, HDL-C, TG) regularly to assess efficacy.
Doctor Notes
- Monitor liver function periodically.
- Educate patients on symptoms of myopathy/rhabdomyolysis.
- Consider dose adjustment in severe renal impairment and with certain interacting drugs.
Patient Guidelines
- Take as directed by your doctor, usually once daily.
- Do not stop taking without consulting your doctor.
- Inform your doctor about any unusual muscle pain, tenderness, or weakness.
- Avoid excessive alcohol consumption.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
Rosuvastatin is not expected to affect the ability to drive or operate machinery. However, if dizziness occurs, exercise caution.
Lifestyle Advice
- Adopt a low-cholesterol diet.
- Engage in regular physical activity.
- Maintain a healthy weight.
- Quit smoking if applicable.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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