Rupa
Generic Name
Rupatadine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rupa 10 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Rupa 10 mg Tablet contains Rupatadine, a non-sedating, long-acting, selective peripheral H1-receptor antagonist. It is used for the symptomatic treatment of allergic rhinitis and urticaria.
Uses & Indications
Dosage
Adults
10 mg once daily
Elderly
No dose adjustment required
Renal_impairment
No dose adjustment required for mild to moderate impairment. Use with caution in severe renal impairment.
How to Take
Take orally with or without food. Do not exceed the recommended dose.
Mechanism of Action
Rupatadine exerts its antihistaminic action primarily by selectively blocking peripheral H1-receptors. It also has an antagonistic effect on platelet-activating factor (PAF).
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly through feces (60.9%) and urine (34.6%) as metabolites.
Half life
Approximately 5.9 hours
Absorption
Rapidly absorbed after oral administration. Tmax is approximately 0.75 hours.
Metabolism
Extensively metabolized by the liver, primarily by CYP3A4, to active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to rupatadine or any of its excipients
- Children under 12 years of age (for 10mg tablets)
Drug Interactions
CNS depressants
Additive effects possible, though less sedating than first-generation antihistamines.
Grapefruit juice
May increase plasma levels of rupatadine
Ketoconazole/Erythromycin
Increased systemic exposure to rupatadine
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, and palpitations. Management is symptomatic and supportive, including gastric lavage and monitoring vital signs.
Pregnancy & Lactation
Use only if clearly needed and the potential benefits outweigh the potential risks to the fetus/infant. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to rupatadine or any of its excipients
- Children under 12 years of age (for 10mg tablets)
Drug Interactions
CNS depressants
Additive effects possible, though less sedating than first-generation antihistamines.
Grapefruit juice
May increase plasma levels of rupatadine
Ketoconazole/Erythromycin
Increased systemic exposure to rupatadine
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, and palpitations. Management is symptomatic and supportive, including gastric lavage and monitoring vital signs.
Pregnancy & Lactation
Use only if clearly needed and the potential benefits outweigh the potential risks to the fetus/infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., DGDA in Bangladesh)
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety in allergic rhinitis and urticaria.
Lab Monitoring
- No specific routine lab monitoring required
- Monitor liver function in patients with hepatic impairment
Doctor Notes
- Advise patients about potential for mild drowsiness, especially at the start of treatment.
- Counsel on avoiding grapefruit juice.
- Ensure patients understand it's for symptomatic relief, not a cure.
Patient Guidelines
- Take the tablet whole with water.
- Do not crush or chew the tablet.
- Consult your doctor if symptoms persist or worsen.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose.
Driving Precautions
May cause drowsiness. Patients should be warned not to drive or operate machinery until their individual response to the drug is known.
Lifestyle Advice
- Avoid known allergens that trigger symptoms.
- Maintain good hygiene to reduce exposure to allergens.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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