Rupa
Generic Name
Rupatadine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rupa 5 mg oral solution | ৳ 75.00 | N/A |
Description
Overview of the medicine
Rupatadine is a non-sedating, long-acting H1-antihistamine used for the symptomatic treatment of seasonal and perennial allergic rhinitis and urticaria.
Uses & Indications
Dosage
Adults
10 mg once daily (e.g., 10 ml of a 1 mg/ml solution or two 5 mg doses).
Elderly
No specific dosage adjustment is usually required, but use with caution due to potential age-related organ function decline.
Renal_impairment
Use with caution. Dosage adjustment may be necessary in severe renal impairment. Consult a physician.
How to Take
Administer orally. Can be taken with or without food. Use the provided measuring device for accurate dosing.
Mechanism of Action
Rupatadine acts as a selective peripheral H1-receptor antagonist. It also demonstrates antagonist activity at platelet-activating factor (PAF) receptors at higher concentrations, contributing to its anti-allergic effects.
Pharmacokinetics
Onset
Within 1 hour.
Excretion
Eliminated primarily via feces (approximately 60%) and urine (approximately 40%) as metabolites.
Half life
Approximately 5.9 hours (for the parent compound, prolonged for active metabolites).
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations (Cmax) are reached approximately 0.75-1.5 hours after intake.
Metabolism
Extensively metabolized, primarily by cytochrome P450 (CYP3A4) isoenzymes, undergoing significant first-pass metabolism.
Side Effects
Contraindications
- Hypersensitivity to rupatadine or to any of the excipients.
- Not recommended for children under 2 years of age.
Drug Interactions
Grapefruit juice
Avoid consumption of grapefruit juice, as it can increase systemic exposure to rupatadine.
CNS depressants/Alcohol
Concomitant use with CNS depressants or alcohol may potentiate sedative effects and impair psychomotor performance.
Ketoconazole/Erythromycin
Coadministration significantly increases systemic exposure to rupatadine.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote for rupatadine.
Pregnancy & Lactation
Use only if clearly needed and the potential benefits outweigh the potential risks to the fetus or infant. Limited data are available. Consult a physician.
Side Effects
Contraindications
- Hypersensitivity to rupatadine or to any of the excipients.
- Not recommended for children under 2 years of age.
Drug Interactions
Grapefruit juice
Avoid consumption of grapefruit juice, as it can increase systemic exposure to rupatadine.
CNS depressants/Alcohol
Concomitant use with CNS depressants or alcohol may potentiate sedative effects and impair psychomotor performance.
Ketoconazole/Erythromycin
Coadministration significantly increases systemic exposure to rupatadine.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote for rupatadine.
Pregnancy & Lactation
Use only if clearly needed and the potential benefits outweigh the potential risks to the fetus or infant. Limited data are available. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 24 months when unopened. Check product label for specific shelf life and expiry date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Patent expired for generic versions
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of rupatadine in the symptomatic treatment of allergic rhinitis and chronic urticaria across various age groups, including pediatric populations.
Lab Monitoring
- Not routinely required for therapeutic use.
Doctor Notes
- Counsel patients and caregivers on proper dosing using the provided measuring device to avoid errors.
- Advise patients on potential CNS effects such as drowsiness and to avoid activities requiring mental alertness if affected.
- Be aware of potential drug interactions, especially with CYP3A4 inhibitors, and adjust therapy accordingly.
- Monitor for clinical improvement and potential adverse effects.
Patient Guidelines
- Always follow your doctor's instructions regarding dose and duration of treatment.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking, including herbal supplements and over-the-counter drugs.
- If symptoms do not improve or worsen, consult your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause drowsiness. Exercise caution when driving or operating machinery, particularly at the beginning of treatment or after a dose increase.
Lifestyle Advice
- Avoid driving or operating machinery if you experience drowsiness, especially at the start of treatment.
- Avoid consuming alcohol while taking this medicine as it may increase sedative effects.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Rupa Brand
Other medicines available under the same brand name
