Rupastar
Generic Name
Rupatadine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rupastar 10 mg tablet | ৳ 10.00 | N/A |
Description
Overview of the medicine
Rupatadine is a second-generation antihistamine with selective peripheral H1-receptor antagonist activity. It is used for the symptomatic treatment of allergic rhinitis and urticaria.
Uses & Indications
Dosage
Adults
10 mg once daily
Elderly
No special dose adjustment is required in elderly patients.
Renal_impairment
Caution is advised in patients with renal impairment (creatinine clearance <10 mL/min).
How to Take
Oral administration. Can be taken with or without food.
Mechanism of Action
Rupatadine acts as a long-acting, selective peripheral H1-receptor antagonist. It also has an inhibitory effect on platelet-activating factor (PAF) and mast cell degranulation, contributing to its anti-allergic properties.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly via feces (60.9%) and urine (34.6%) as metabolites.
Half life
Approximately 5.9 hours
Absorption
Rapidly absorbed after oral administration, Tmax approximately 0.5-1 hour. Food increases systemic exposure (AUC and Cmax) by about 23% and 26% respectively, without significant clinical relevance.
Metabolism
Extensively metabolized by the liver via CYP3A4 into active and inactive metabolites (e.g., desloratadine, 3-hydroxydesloratadine).
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients
Drug Interactions
Grapefruit juice
Avoid coadministration with grapefruit juice, as it may increase rupatadine levels.
Ketoconazole, Erythromycin, Diltiazem
Coadministration with strong CYP3A4 inhibitors like ketoconazole or erythromycin may increase systemic exposure of rupatadine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, dry mouth. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy: Limited data. Use only if clearly needed and potential benefit outweighs potential risk to the fetus. Lactation: Unknown if excreted in human milk. Exercise caution.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients
Drug Interactions
Grapefruit juice
Avoid coadministration with grapefruit juice, as it may increase rupatadine levels.
Ketoconazole, Erythromycin, Diltiazem
Coadministration with strong CYP3A4 inhibitors like ketoconazole or erythromycin may increase systemic exposure of rupatadine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, dry mouth. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy: Limited data. Use only if clearly needed and potential benefit outweighs potential risk to the fetus. Lactation: Unknown if excreted in human milk. Exercise caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by drug regulatory authorities (e.g., EMA, DGDA)
Patent Status
Patent expired in many countries, generic versions available
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety in allergic rhinitis and urticaria.
Doctor Notes
- Advise patients about potential somnolence.
- Consider drug interactions, especially with CYP3A4 inhibitors.
- No dose adjustment needed for hepatic impairment, but caution with severe renal impairment.
Patient Guidelines
- Take as directed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Rupatadine can cause somnolence. Patients should be advised to exercise caution when driving or operating machinery until they know how they react to the medication.
Lifestyle Advice
- Avoid alcohol consumption as it may increase drowsiness.
- Identify and avoid known allergens.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Rupastar Brand
Other medicines available under the same brand name
