rupoma
Generic Name
rupatadine 5 mg oral solution
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rupoma 5 mg oral solution | ৳ 60.00 | N/A |
Description
Overview of the medicine
Rupoma-5 mg Oral Solution contains rupatadine, an antihistamine used to relieve symptoms of allergic rhinitis (e.g., sneezing, runny nose, itchy eyes) and chronic idiopathic urticaria (hives). It is particularly suitable for pediatric use.
Uses & Indications
Dosage
Adults
Not typically indicated for adults at this strength; adults usually take 10 mg once daily (tablet formulation).
Renal_impairment
No specific dose adjustment is considered necessary for mild to moderate renal impairment, but caution is advised in severe cases.
Hepatic_impairment
Use with caution in patients with hepatic impairment, as rupatadine is extensively metabolized in the liver.
Children_2_11_years
5 mg (5 ml) once daily with or without food.
Children_under_2_years
Not recommended due to insufficient data.
How to Take
Administer orally. The solution can be taken with or without food. Use the provided measuring cup or spoon for accurate dosing.
Mechanism of Action
Rupatadine is a non-sedating, selective peripheral H1-receptor antagonist. It also has antagonistic activity against platelet-activating factor (PAF) and inhibits the degranulation of mast cells, thereby reducing the release of inflammatory mediators.
Pharmacokinetics
Onset
Onset of action typically observed within 1 to 2 hours.
Excretion
Approximately 60% of the dose is excreted via feces and 38% via urine, mainly as metabolites.
Half life
The mean elimination half-life is approximately 6 to 9 hours.
Absorption
Rapidly absorbed after oral administration. The mean absolute bioavailability is low (approximately 20-30%) due to extensive first-pass metabolism.
Metabolism
Extensively metabolized, primarily by the liver via the cytochrome P450 system (CYP3A4) to active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to rupatadine or to any of the excipients.
- Not recommended for children under 2 years of age.
Drug Interactions
CNS Depressants
May potentiate the sedative effects of alcohol and other CNS depressants.
Grapefruit Juice
May increase rupatadine systemic exposure; avoid co-consumption.
Ketoconazole and Erythromycin
Co-administration may increase rupatadine exposure, requiring caution.
Storage
Store below 30°C in a dry place, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, headache, and tachycardia. Treatment should be symptomatic and supportive, including general supportive measures and monitoring of vital signs.
Pregnancy & Lactation
Pregnancy Category B. Animal studies have not shown adverse effects, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. It is unknown whether rupatadine is excreted in human milk; caution is advised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to rupatadine or to any of the excipients.
- Not recommended for children under 2 years of age.
Drug Interactions
CNS Depressants
May potentiate the sedative effects of alcohol and other CNS depressants.
Grapefruit Juice
May increase rupatadine systemic exposure; avoid co-consumption.
Ketoconazole and Erythromycin
Co-administration may increase rupatadine exposure, requiring caution.
Storage
Store below 30°C in a dry place, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, headache, and tachycardia. Treatment should be symptomatic and supportive, including general supportive measures and monitoring of vital signs.
Pregnancy & Lactation
Pregnancy Category B. Animal studies have not shown adverse effects, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. It is unknown whether rupatadine is excreted in human milk; caution is advised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture. Use within 6 months after opening.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
Clinical Trials
Rupatadine has undergone extensive clinical trials demonstrating its efficacy and safety for the symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria in adults and children.
Lab Monitoring
- No specific routine lab monitoring is required for rupatadine.
Doctor Notes
- Emphasize the importance of accurate dosing using the provided measuring device, especially for pediatric patients.
- Advise patients about the potential for drowsiness and its implications for driving or operating machinery.
- Inform about drug interactions, particularly with grapefruit juice and other CNS depressants.
Patient Guidelines
- Do not exceed the prescribed dose, especially for children.
- This medicine may cause drowsiness; avoid driving or operating heavy machinery until you know how it affects you.
- Avoid alcohol consumption while taking this medication as it may increase sedative effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Rupatadine may cause drowsiness. Patients should be warned that driving or operating machinery may be impaired, especially during the initial treatment period or if taken with alcohol.
Lifestyle Advice
- Identify and avoid known allergens or triggers for your allergies.
- Maintain good indoor air quality to minimize exposure to dust mites, pet dander, and pollen.
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