Rupsol
Generic Name
Rupatadine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rupsol 5 oral paste | ৳ 75.00 | N/A |
Description
Overview of the medicine
Rupatadine is a non-sedating, long-acting antihistamine with selective peripheral H1-receptor antagonist activity, used for symptomatic treatment of allergic rhinitis and urticaria.
Uses & Indications
Dosage
Adults
One 10 mg tablet once daily.
Elderly
No dose adjustment required for elderly patients.
Renal_impairment
Use with caution in patients with severe renal impairment.
How to Take
Oral. Can be taken with or without food.
Mechanism of Action
Blocks peripheral H1 receptors, reducing histamine-mediated allergic symptoms. Also inhibits PAF (Platelet-Activating Factor) and mast cell degranulation.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted via feces (60.9%) and urine (34.6%) as metabolites.
Half life
Approximately 5.9 hours
Absorption
Rapidly absorbed after oral administration, peak plasma concentration reached in approximately 0.5-1 hour.
Metabolism
Extensively metabolized in the liver by cytochrome P450 (CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Children under 12 years of age for 10 mg tablet.
Drug Interactions
Grapefruit juice
Increases plasma levels of rupatadine.
Ketoconazole/Erythromycin
Increases systemic exposure to rupatadine.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture.
Overdose
Symptoms may include drowsiness. Management is symptomatic and supportive; consider gastric lavage and activated charcoal.
Pregnancy & Lactation
Category B in pregnancy. Use with caution during pregnancy and lactation; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Children under 12 years of age for 10 mg tablet.
Drug Interactions
Grapefruit juice
Increases plasma levels of rupatadine.
Ketoconazole/Erythromycin
Increases systemic exposure to rupatadine.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture.
Overdose
Symptoms may include drowsiness. Management is symptomatic and supportive; consider gastric lavage and activated charcoal.
Pregnancy & Lactation
Category B in pregnancy. Use with caution during pregnancy and lactation; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Patent expired for generic formulation
Clinical Trials
Extensive clinical trials have demonstrated its efficacy and safety for allergic rhinitis and urticaria.
Lab Monitoring
- No specific lab monitoring required for routine use.
Doctor Notes
- Advise patients about potential drowsiness, especially when starting treatment.
- Consider drug interactions with strong CYP3A4 inhibitors.
Patient Guidelines
- Take as directed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause drowsiness; use caution.
Lifestyle Advice
- Avoid driving or operating heavy machinery if you experience drowsiness.
- Limit alcohol consumption as it may increase drowsiness.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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