Salix
Generic Name
Salix
Manufacturer
PharmaGlobal Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| salix 2 mg syrup | ৳ 14.47 | N/A |
Description
Overview of the medicine
Salix 2 mg Syrup is an antihistaminic medication used to relieve symptoms of allergic reactions such as sneezing, runny nose, watery eyes, and itching. It helps to block the action of histamine, a natural substance in the body that causes allergic symptoms.
Uses & Indications
Dosage
Adults
Adults and adolescents 12 years and older: 10 ml (4 mg) once daily. In some cases, 5 ml (2 mg) once daily may be sufficient.
Elderly
No specific dose adjustment is required unless renal impairment is present. Use with caution.
Renal_impairment
Dosage adjustment may be necessary. For mild to moderate impairment, 5 ml (2 mg) once daily. Not recommended for severe impairment.
How to Take
Take orally, with or without food, usually once daily. Use a measuring spoon or cup provided with the syrup for accurate dosing.
Mechanism of Action
Salix acts as a selective peripheral H1-receptor antagonist. It competitively binds to H1 receptors, thereby preventing the binding and action of histamine. This blocks the cascade of allergic reactions mediated by histamine, leading to relief of symptoms.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Mainly excreted via the urine as metabolites and unchanged drug. Small amount excreted in feces.
Half life
Approximately 10-15 hours
Absorption
Rapidly absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver to inactive metabolites. Minimal first-pass metabolism.
Side Effects
Contraindications
- Hypersensitivity to Salix or any of its excipients.
- Patients with severe renal impairment (CrCl < 10 mL/min).
Drug Interactions
Ketoconazole, Erythromycin
May increase plasma levels of Salix, potentially leading to increased side effects.
CNS Depressants (e.g., alcohol, sedatives)
Increased CNS depressant effects.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, headache, and anticholinergic effects. Treatment is symptomatic and supportive; gastric lavage or activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefits outweigh the risks. Excreted in breast milk, so caution is advised during lactation; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Salix or any of its excipients.
- Patients with severe renal impairment (CrCl < 10 mL/min).
Drug Interactions
Ketoconazole, Erythromycin
May increase plasma levels of Salix, potentially leading to increased side effects.
CNS Depressants (e.g., alcohol, sedatives)
Increased CNS depressant effects.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, headache, and anticholinergic effects. Treatment is symptomatic and supportive; gastric lavage or activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefits outweigh the risks. Excreted in breast milk, so caution is advised during lactation; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent pending
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Salix in treating allergic rhinitis and urticaria in both adult and pediatric populations. Phase III trials showed significant reduction in symptom scores compared to placebo.
Lab Monitoring
- Liver function tests (in patients with pre-existing hepatic impairment or prolonged use).
- Renal function tests (in patients with pre-existing renal impairment).
Doctor Notes
- Advise patients about potential drowsiness, especially at the initiation of therapy.
- Consider renal function in elderly patients or those with known kidney impairment before prescribing.
- Review concomitant medications for potential interactions, particularly CNS depressants and CYP3A4 inhibitors.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid driving or operating machinery if you experience drowsiness.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness. Patients should be advised not to drive or operate hazardous machinery until they know how Salix affects them.
Lifestyle Advice
- Avoid alcohol consumption while taking Salix as it may increase drowsiness.
- Stay hydrated by drinking plenty of fluids.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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