Salix
Generic Name
Salixum 4 mg Tablet
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| salix 4 mg tablet | ৳ 0.34 | N/A |
Description
Overview of the medicine
Salix 4 mg Tablet is a potent diuretic used to treat conditions characterized by fluid retention (edema), such as congestive heart failure, liver cirrhosis, and kidney disease. It also helps manage high blood pressure.
Uses & Indications
Dosage
Adults
Initial dose 4 mg once daily. May be increased up to 20 mg per day in divided doses depending on patient response. For hypertension, 4 mg once daily, adjusted based on blood pressure response.
Elderly
Lower initial doses (e.g., 2 mg) and careful titration are recommended due to potential for greater sensitivity and increased risk of electrolyte imbalance.
Renal_impairment
Dosage adjustment required. Lower doses and careful monitoring of renal function and electrolytes are necessary. Contraindicated in anuria.
How to Take
Take Salix 4 mg Tablet orally, with or without food, preferably in the morning to avoid nocturnal diuresis. Follow your doctor's instructions carefully.
Mechanism of Action
Salixum, a loop diuretic, acts by inhibiting the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle in the kidney. This prevents the reabsorption of sodium, potassium, and chloride ions, leading to increased excretion of water, sodium, chloride, and other electrolytes.
Pharmacokinetics
Onset
Oral: 30-60 minutes; IV: 5 minutes.
Excretion
Mainly via the kidneys (urine), with some fecal excretion.
Half life
Approximately 0.5-2 hours, prolonged in renal impairment.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability varies but is generally good.
Metabolism
Primarily hepatic, with some renal metabolism.
Side Effects
Contraindications
- Hypersensitivity to Salixum or sulfonamide derivatives
- Anuria (absence of urine production)
- Severe electrolyte depletion (e.g., severe hypokalemia, hyponatremia)
- Hepatic coma and precoma
Drug Interactions
Lithium
Reduced renal clearance of lithium, leading to increased lithium levels and toxicity.
Corticosteroids
Increased risk of hypokalemia.
Aminoglycoside antibiotics
Increased risk of ototoxicity (ear damage).
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the diuretic and antihypertensive effects of Salixum.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dehydration, electrolyte depletion (e.g., hypokalemia, hypochloremia, hyponatremia), hypotension, and possibly renal failure. Treatment is symptomatic and supportive, focusing on fluid and electrolyte replacement.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Salixum passes into breast milk; therefore, caution is advised during lactation. Consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to Salixum or sulfonamide derivatives
- Anuria (absence of urine production)
- Severe electrolyte depletion (e.g., severe hypokalemia, hyponatremia)
- Hepatic coma and precoma
Drug Interactions
Lithium
Reduced renal clearance of lithium, leading to increased lithium levels and toxicity.
Corticosteroids
Increased risk of hypokalemia.
Aminoglycoside antibiotics
Increased risk of ototoxicity (ear damage).
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the diuretic and antihypertensive effects of Salixum.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dehydration, electrolyte depletion (e.g., hypokalemia, hypochloremia, hyponatremia), hypotension, and possibly renal failure. Treatment is symptomatic and supportive, focusing on fluid and electrolyte replacement.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Salixum passes into breast milk; therefore, caution is advised during lactation. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Salixum is a well-established loop diuretic with extensive clinical data supporting its efficacy and safety in various indications.
Lab Monitoring
- Serum electrolytes (sodium, potassium, chloride, magnesium, calcium)
- Kidney function tests (creatinine, BUN)
- Blood pressure
- Fluid balance
Doctor Notes
- Strict monitoring of fluid and electrolyte status is crucial, especially in elderly patients or those with pre-existing renal or hepatic impairment.
- Advise patients on symptoms of dehydration and electrolyte imbalance and instruct them to seek medical attention if these occur.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking Salixum without consulting your doctor, even if you feel better.
- Report any symptoms of dehydration or electrolyte imbalance (e.g., excessive thirst, muscle weakness, confusion) to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Salix 4 mg Tablet may cause dizziness, especially at the start of treatment or when changing doses. Avoid driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Maintain a low-sodium diet as advised by your doctor.
- Stay hydrated by drinking adequate fluids unless otherwise instructed by your doctor.
- Regularly monitor your weight to track fluid changes.
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Global Brand Names
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