Saltide
Generic Name
Salmeterol + Fluticasone Propionate
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| saltide 100 mcg inhaler | ৳ 250.00 | N/A |
Description
Overview of the medicine
Saltide 100 mcg Inhaler is a combination medicine containing Salmeterol (a long-acting beta2-agonist) and Fluticasone Propionate (an inhaled corticosteroid). It is used for the regular treatment of asthma and chronic obstructive pulmonary disease (COPD) to improve breathing and reduce inflammation in the airways.
Uses & Indications
Dosage
Adults
One to two inhalations twice daily (morning and evening). The highest strength (500/50 mcg) is not indicated for initial asthma therapy.
Elderly
No dosage adjustment is required for elderly patients.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
For inhalation only. Shake the inhaler well before each use. Patients should be instructed on proper inhaler technique to ensure optimal drug delivery to the lungs. After inhaling, rinse your mouth with water and spit it out to minimize the risk of oral candidiasis (thrush).
Mechanism of Action
Salmeterol acts as a selective long-acting beta2-adrenergic agonist, causing bronchodilation by relaxing the smooth muscles of the airways. Fluticasone Propionate is a corticosteroid with potent anti-inflammatory effects, reducing airway inflammation and hyperresponsiveness.
Pharmacokinetics
Onset
Bronchodilation with salmeterol typically starts within 10-20 minutes, with peak effect in 2 hours. The anti-inflammatory effect of fluticasone takes several days to weeks to become fully apparent.
Excretion
Salmeterol and its metabolites are primarily excreted via feces, with a small amount in urine. Fluticasone and its metabolites are excreted mainly in feces.
Half life
Salmeterol: approximately 5.5 hours. Fluticasone: approximately 8 hours.
Absorption
Following inhalation, both salmeterol and fluticasone are absorbed from the lungs. A portion of the dose is swallowed and absorbed from the GI tract but undergoes significant first-pass metabolism. Systemic absorption is low.
Metabolism
Both salmeterol and fluticasone are extensively metabolized in the liver, primarily by the cytochrome P450 3A4 (CYP3A4) enzyme system.
Side Effects
Contraindications
- •Hypersensitivity to salmeterol, fluticasone propionate, or any excipient.
- •Primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required.
Drug Interactions
Beta-blockers
May antagonize the effects of salmeterol and potentially induce bronchospasm in asthmatic patients. Non-cardioselective beta-blockers should generally be avoided.
Diuretics (non-potassium sparing)
May enhance hypokalemic effect of beta2-agonists.
Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
Concomitant use may increase systemic exposure to salmeterol and fluticasone, leading to increased risk of cardiovascular adverse effects (salmeterol) and systemic corticosteroid effects (fluticasone).
Storage
Store below 30°C in a dry place, away from direct sunlight and heat. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of salmeterol overdose include tremor, headache, tachycardia, and palpitations. Fluticasone overdose, especially with chronic use, may lead to systemic corticosteroid effects like adrenal suppression. Treatment is supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy and lactation should be considered only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, specific to packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent (generic versions available)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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