Saltide
Generic Name
Salmeterol + Fluticasone Propionate
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
saltide 100 mcg inhaler | ৳ 250.00 | N/A |
Description
Overview of the medicine
Saltide 100 mcg Inhaler is a combination medicine containing Salmeterol (a long-acting beta2-agonist) and Fluticasone Propionate (an inhaled corticosteroid). It is used for the regular treatment of asthma and chronic obstructive pulmonary disease (COPD) to improve breathing and reduce inflammation in the airways.
Uses & Indications
Dosage
Adults
One to two inhalations twice daily (morning and evening). The highest strength (500/50 mcg) is not indicated for initial asthma therapy.
Elderly
No dosage adjustment is required for elderly patients.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
For inhalation only. Shake the inhaler well before each use. Patients should be instructed on proper inhaler technique to ensure optimal drug delivery to the lungs. After inhaling, rinse your mouth with water and spit it out to minimize the risk of oral candidiasis (thrush).
Mechanism of Action
Salmeterol acts as a selective long-acting beta2-adrenergic agonist, causing bronchodilation by relaxing the smooth muscles of the airways. Fluticasone Propionate is a corticosteroid with potent anti-inflammatory effects, reducing airway inflammation and hyperresponsiveness.
Pharmacokinetics
Onset
Bronchodilation with salmeterol typically starts within 10-20 minutes, with peak effect in 2 hours. The anti-inflammatory effect of fluticasone takes several days to weeks to become fully apparent.
Excretion
Salmeterol and its metabolites are primarily excreted via feces, with a small amount in urine. Fluticasone and its metabolites are excreted mainly in feces.
Half life
Salmeterol: approximately 5.5 hours. Fluticasone: approximately 8 hours.
Absorption
Following inhalation, both salmeterol and fluticasone are absorbed from the lungs. A portion of the dose is swallowed and absorbed from the GI tract but undergoes significant first-pass metabolism. Systemic absorption is low.
Metabolism
Both salmeterol and fluticasone are extensively metabolized in the liver, primarily by the cytochrome P450 3A4 (CYP3A4) enzyme system.
Side Effects
Contraindications
- Hypersensitivity to salmeterol, fluticasone propionate, or any excipient.
- Primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required.
Drug Interactions
Beta-blockers
May antagonize the effects of salmeterol and potentially induce bronchospasm in asthmatic patients. Non-cardioselective beta-blockers should generally be avoided.
Diuretics (non-potassium sparing)
May enhance hypokalemic effect of beta2-agonists.
Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
Concomitant use may increase systemic exposure to salmeterol and fluticasone, leading to increased risk of cardiovascular adverse effects (salmeterol) and systemic corticosteroid effects (fluticasone).
Storage
Store below 30°C in a dry place, away from direct sunlight and heat. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of salmeterol overdose include tremor, headache, tachycardia, and palpitations. Fluticasone overdose, especially with chronic use, may lead to systemic corticosteroid effects like adrenal suppression. Treatment is supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy and lactation should be considered only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to salmeterol, fluticasone propionate, or any excipient.
- Primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required.
Drug Interactions
Beta-blockers
May antagonize the effects of salmeterol and potentially induce bronchospasm in asthmatic patients. Non-cardioselective beta-blockers should generally be avoided.
Diuretics (non-potassium sparing)
May enhance hypokalemic effect of beta2-agonists.
Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
Concomitant use may increase systemic exposure to salmeterol and fluticasone, leading to increased risk of cardiovascular adverse effects (salmeterol) and systemic corticosteroid effects (fluticasone).
Storage
Store below 30°C in a dry place, away from direct sunlight and heat. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of salmeterol overdose include tremor, headache, tachycardia, and palpitations. Fluticasone overdose, especially with chronic use, may lead to systemic corticosteroid effects like adrenal suppression. Treatment is supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy and lactation should be considered only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, specific to packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent (generic versions available)
WHO Essential Medicine
YesClinical Trials
The combination of salmeterol and fluticasone propionate has been extensively studied in numerous clinical trials, demonstrating its efficacy and safety in the long-term management of asthma and COPD, leading to improved lung function, reduced symptoms, and fewer exacerbations.
Lab Monitoring
- Regular monitoring of growth in children and adolescents receiving long-term ICS.
- Monitoring for signs of adrenal suppression or hyperglycemia, particularly in patients receiving high doses for prolonged periods.
Doctor Notes
- Emphasize proper inhaler technique to optimize drug delivery and minimize side effects like oral candidiasis.
- Instruct patients that Saltide is a controller medication and not for acute bronchospasm relief; ensure they have an appropriate rescue inhaler.
- Advise monitoring for systemic corticosteroid side effects with high-dose or prolonged use, especially in susceptible populations.
Patient Guidelines
- Use the inhaler regularly as prescribed, even when you feel well, for optimal control of asthma or COPD.
- Do not use Saltide for immediate relief of sudden breathing problems; use your prescribed rescue inhaler for acute attacks.
- Rinse your mouth with water and spit it out after each dose to prevent oral thrush.
- Learn and practice proper inhaler technique with your doctor or pharmacist to ensure the medicine reaches your lungs effectively.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Saltide is unlikely to affect the ability to drive or operate machinery. However, if side effects like dizziness or blurred vision occur, avoid such activities.
Lifestyle Advice
- Avoid triggers that worsen your asthma or COPD.
- Quitting smoking is crucial for patients with COPD and beneficial for asthma management.
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