Sandom
Generic Name
Domperidone 5 mg/5 mL suspension
Manufacturer
Renata Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sandom 5 mg suspension | ৳ 28.18 | N/A |
Description
Overview of the medicine
Sandom 5 mg Suspension is an oral suspension containing Domperidone, used to treat nausea, vomiting, and certain digestive disorders by increasing the movement of food through the stomach and intestines.
Uses & Indications
Dosage
Adults
Adults: 10 mg (10 mL) three times daily, 15-30 minutes before meals. Maximum duration of treatment should not usually exceed one week. For severe or persistent cases, dosage may be adjusted by a physician.
Elderly
Elderly: Use with caution. Start with lower doses and monitor for adverse effects due to potential for impaired renal or hepatic function.
Renal_impairment
Renal impairment: Reduce dosing frequency to once or twice daily, depending on severity of impairment, due to prolonged half-life. Not recommended for severe renal impairment.
How to Take
Take orally, 15-30 minutes before meals. Shake the bottle well before each use. Measure the dose accurately using the provided measuring spoon or cup.
Mechanism of Action
Domperidone acts as a peripheral dopamine D2 receptor antagonist. It blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) in the brain, thereby inhibiting nausea and vomiting. It also blocks peripheral dopamine receptors in the gastrointestinal wall, which leads to increased gastric motility and faster gastric emptying without affecting gastric secretions.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Approximately 60% excreted in feces (mainly as metabolites) and 30-31% in urine (as metabolites). Only a small amount is excreted unchanged.
Half life
Approximately 7-9 hours (prolonged in severe renal impairment).
Absorption
Rapidly absorbed after oral administration, but extensively metabolized in the gut wall and liver (first-pass metabolism). Peak plasma concentrations are reached within 30-60 minutes.
Metabolism
Extensively metabolized in the liver by CYP3A4, with minor contributions from CYP1A2 and CYP2E1.
Side Effects
Contraindications
- •Hypersensitivity to Domperidone or any component of the suspension.
- •Patients with known prolongation of cardiac conduction intervals, particularly QTc.
- •Patients with significant underlying cardiac diseases (e.g., congestive heart failure).
- •Patients with hepatic impairment (moderate to severe).
- •Patients with pituitary tumor (prolactinoma).
- •Concomitant use with potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin).
- •Concomitant use with QTc-prolonging drugs.
- •Patients with gastrointestinal hemorrhage, mechanical obstruction, or perforation.
Drug Interactions
Anticholinergics (e.g., Atropine, Dicyclomine)
May antagonize the prokinetic effect of Domperidone.
Dopamine agonists (e.g., Bromocriptine, Cabergoline)
Domperidone may antagonize their effects.
QTc-prolonging drugs (e.g., Amiodarone, Haloperidol, Quinidine)
Increased risk of cardiac arrhythmias. Concomitant use is contraindicated.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin, Clarithromycin, Ritonavir)
Potentiate the effects of Domperidone by increasing plasma levels, increasing risk of QTc prolongation. Concomitant use is contraindicated.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, disorientation, extrapyramidal reactions (e.g., involuntary muscle movements, dystonia), and convulsions. Treatment is symptomatic and supportive, including gastric lavage or activated charcoal. Anticholinergic, anti-Parkinsonian drugs may be useful for extrapyramidal reactions.
Pregnancy & Lactation
Pregnancy Category C: Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lactation: Domperidone is excreted in breast milk in small amounts. Breastfeeding is generally not recommended if Domperidone use is essential.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date, check specific packaging for details.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent (generic available)
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Global Brand Names
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