Sapox
Generic Name
Cefixime
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sapox 125 mg suspension | ৳ 70.00 | N/A |
Description
Overview of the medicine
Sapox 125 mg Suspension contains Cefixime, a third-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections in children.
Uses & Indications
Dosage
Adults
Adults typically use tablet forms. If suspension is used, consult a physician for appropriate dosing based on weight and infection severity (e.g., 400 mg once daily).
Children
For children 6 months to 12 years: 8 mg/kg/day administered as a single dose or in two divided doses every 12 hours. Max 400 mg/day.
Renal_impairment
Dosage adjustment is necessary for patients with severe renal impairment (creatinine clearance < 30 ml/min).
How to Take
Shake the bottle well before each use. Administer orally with a measuring spoon or cup. Can be taken with or without food.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Typically, clinical improvement is observed within 24-48 hours.
Excretion
Primarily renal excretion (approximately 50% unchanged in urine), with some biliary excretion.
Half life
Plasma half-life is usually 3 to 4 hours.
Absorption
Approximately 40-50% orally absorbed. Food may delay absorption but does not significantly affect the extent of absorption.
Metabolism
Cefixime is largely excreted unchanged; there is no evidence of significant metabolism.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Warfarin
May increase prothrombin time (INR), requiring closer monitoring.
Nifedipine
Increases peak plasma level and AUC of Cefixime.
Carbamazepine
May increase plasma concentrations of carbamazepine.
Oral Anticoagulants
Enhanced anticoagulant effect observed with some cephalosporins.
Storage
Store the dry powder below 30°C, protected from light and moisture. Keep out of reach of children. Store reconstituted suspension in a refrigerator (2-8°C); do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Warfarin
May increase prothrombin time (INR), requiring closer monitoring.
Nifedipine
Increases peak plasma level and AUC of Cefixime.
Carbamazepine
May increase plasma concentrations of carbamazepine.
Oral Anticoagulants
Enhanced anticoagulant effect observed with some cephalosporins.
Storage
Store the dry powder below 30°C, protected from light and moisture. Keep out of reach of children. Store reconstituted suspension in a refrigerator (2-8°C); do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months for unreconstituted powder. Reconstituted suspension is stable for 7-14 days when stored in a refrigerator (2-8°C).
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety across various bacterial infections in pediatric and adult populations.
Lab Monitoring
- Monitor renal function (creatinine clearance) in patients with pre-existing renal impairment.
- Monitor prothrombin time (INR) in patients concurrently receiving anticoagulants.
- Liver function tests and complete blood count (CBC) may be monitored during prolonged therapy.
Doctor Notes
- Emphasize the importance of completing the full course of therapy to prevent antibiotic resistance.
- Advise parents/caregivers to measure doses accurately using the provided measuring device.
- Be aware of potential cross-reactivity in patients with a history of penicillin allergy.
Patient Guidelines
- Complete the full course of antibiotics as prescribed, even if symptoms improve.
- Do not save medication for future use or share it with others.
- Report any severe or persistent side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Cefixime may cause dizziness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how Cefixime affects them.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Ensure adequate fluid intake unless otherwise advised by your doctor.
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Global Brand Names
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