Sasolin D
Generic Name
Desloratadine + Pseudoephedrine Sulfate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sasolin d 04 mg capsule | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Sasolin D is a combination medicine containing an antihistamine (Desloratadine) and a decongestant (Pseudoephedrine Sulfate). It is used to relieve symptoms associated with seasonal allergic rhinitis, including sneezing, runny nose, itching of the nose or throat, watery eyes, and nasal congestion.
Uses & Indications
Dosage
Adults
One extended-release tablet orally once daily.
Elderly
Dosage adjustment may be necessary in elderly patients with impaired renal function.
Renal_impairment
For patients with renal impairment, a reduced frequency (e.g., every other day) may be recommended.
How to Take
Take the tablet whole with a glass of water, with or without food. Do not crush, chew, or break the tablet.
Mechanism of Action
Desloratadine is a non-sedating, long-acting histamine antagonist with selective H1-receptor antagonist activity. Pseudoephedrine is a sympathomimetic amine that directly and indirectly stimulates adrenergic receptors, leading to vasoconstriction and reduced nasal congestion.
Pharmacokinetics
Onset
Symptom relief typically begins within 30-60 minutes.
Excretion
Desloratadine and its metabolites are primarily excreted via urine and feces. Pseudoephedrine is primarily excreted unchanged in the urine, with urinary pH influencing the rate of excretion.
Half life
Desloratadine has a mean half-life of approximately 27 hours. Pseudoephedrine has a half-life of 9-16 hours (for extended-release).
Absorption
Both desloratadine and pseudoephedrine are well absorbed after oral administration. Desloratadine's peak plasma concentration is reached in approximately 3 hours. Pseudoephedrine's peak plasma concentration from extended-release forms is typically between 4-6 hours.
Metabolism
Desloratadine is extensively metabolized to 3-hydroxydesloratadine, an active metabolite. Pseudoephedrine is incompletely metabolized in the liver to an inactive metabolite.
Side Effects
Contraindications
- •Hypersensitivity to desloratadine, loratadine, pseudoephedrine, or any component of the formulation
- •Patients with narrow-angle glaucoma
- •Urinary retention
- •Severe hypertension
- •Severe coronary artery disease
- •Patients receiving monoamine oxidase (MAO) inhibitors or within 14 days of discontinuing MAO inhibitor therapy
Drug Interactions
Digoxin
Increased risk of cardiac arrhythmias with pseudoephedrine.
MAO Inhibitors
Concurrent use or use within 14 days of stopping MAO inhibitors can cause a hypertensive crisis.
Antihypertensive drugs
Pseudoephedrine may reduce the effectiveness of antihypertensive agents (e.g., beta-blockers, methyldopa, reserpine).
Alcohol/CNS depressants
May enhance drowsiness.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, hypertension, nervousness, and convulsions. Treatment is symptomatic and supportive, including gastric lavage or activated charcoal, and monitoring vital signs.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding as both components are excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
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Global Brand Names
International brand names for this medicine
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