Oral administration, with or without food. Can be taken at any time of day but ideally at the same time each day.

Amlodipine inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. This reduces peripheral vascular resistance and lowers blood pressure. In angina, it dilates coronary arteries and arterioles, increasing myocardial oxygen delivery.

• •Hypersensitivity to amlodipine or dihydropyridine derivatives
• •Severe hypotension
• •Cardiogenic shock
• •Outflow tract obstruction of the left ventricle (e.g., high grade aortic stenosis)
• •Hemodynamically unstable heart failure after acute myocardial infarction

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms include excessive peripheral vasodilation with marked hypotension and possibly a reflex tachycardia. Management: supportive care, gastric lavage/activated charcoal, monitor cardiac and respiratory function, administer IV fluids and vasopressors if needed. Calcium gluconate may be beneficial.

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Small amounts may pass into breast milk; caution advised during lactation.