sb-losak
Generic Name
Losartan Potassium
Manufacturer
SB Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sb losak 25 mg tablet | ৳ 4.50 | N/A |
Description
Overview of the medicine
Losartan is an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension), diabetic nephropathy, and heart failure.
Uses & Indications
Dosage
Adults
Initial dose is usually 50 mg once daily. For 25 mg: May be used as a starting dose in specific conditions or in patients who may be volume depleted. Maintenance dose: 25-100 mg once daily.
Elderly
No initial dosage adjustment is usually required, but a lower starting dose (e.g., 25 mg) may be considered in some elderly patients.
Renal_impairment
No initial dosage adjustment is required for mild to moderate renal impairment. A lower starting dose (e.g., 25 mg) may be considered in severe renal impairment.
How to Take
Take orally, with or without food. It can be taken at any time of the day, but it is recommended to take it at the same time each day to maintain consistent blood levels.
Mechanism of Action
Losartan selectively blocks the binding of angiotensin II to the AT1 receptor found in many tissues. This prevents angiotensin II from causing vasoconstriction and aldosterone release, leading to reduced blood pressure.
Pharmacokinetics
Onset
Peak effect typically occurs within 6 hours. Full antihypertensive effect may take 3-6 weeks.
Excretion
Approximately 35% excreted in urine (4% unchanged losartan, 6% active metabolite) and 60% in feces (43% active metabolite).
Half life
Losartan: Approximately 2 hours. Active metabolite (E-3174): 6-9 hours.
Absorption
Well absorbed from the gastrointestinal tract, undergoes significant first-pass metabolism. Bioavailability is about 33%.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C9 and CYP3A4, to an active carboxylic acid metabolite (E-3174) and inactive metabolites.
Side Effects
Contraindications
- Pregnancy (second and third trimesters)
- Hypersensitivity to Losartan or any component of the formulation
- Co-administration with aliskiren in patients with diabetes mellitus or renal impairment
Drug Interactions
Lithium
May increase serum lithium levels, leading to lithium toxicity.
Aliskiren
Concomitant use in diabetic patients or those with renal impairment is contraindicated due to increased risk of renal impairment, hyperkalemia, and hypotension.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Potassium-sparing diuretics & Potassium supplements
May increase the risk of hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension (low blood pressure) and tachycardia (rapid heartbeat); bradycardia (slow heartbeat) could occur. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Category D in pregnancy (second and third trimesters) due to fetal toxicity. Contraindicated. Not recommended during breastfeeding as it is unknown if Losartan is excreted in human milk.
Side Effects
Contraindications
- Pregnancy (second and third trimesters)
- Hypersensitivity to Losartan or any component of the formulation
- Co-administration with aliskiren in patients with diabetes mellitus or renal impairment
Drug Interactions
Lithium
May increase serum lithium levels, leading to lithium toxicity.
Aliskiren
Concomitant use in diabetic patients or those with renal impairment is contraindicated due to increased risk of renal impairment, hyperkalemia, and hypotension.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Potassium-sparing diuretics & Potassium supplements
May increase the risk of hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension (low blood pressure) and tachycardia (rapid heartbeat); bradycardia (slow heartbeat) could occur. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Category D in pregnancy (second and third trimesters) due to fetal toxicity. Contraindicated. Not recommended during breastfeeding as it is unknown if Losartan is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from manufacturing date, depending on manufacturer.
Availability
Available in pharmacies nationwide.
Approval Status
Approved by regulatory authorities worldwide, including DGDA in Bangladesh.
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Losartan has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in hypertension, heart failure, and diabetic nephropathy (e.g., LIFE study, RENAAL study).
Lab Monitoring
- Blood pressure monitoring regularly
- Serum potassium levels (especially in patients with renal impairment or on potassium-sparing diuretics)
- Renal function (creatinine and BUN) periodically
- Liver function tests (if liver dysfunction is suspected)
Doctor Notes
- Monitor blood pressure, renal function (creatinine, BUN), and serum potassium levels regularly.
- Advise patients about the risk of fetal toxicity and to discontinue immediately if pregnancy is detected.
- Counsel patients on lifestyle modifications to enhance therapeutic outcomes.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor, even if you feel well.
- Inform your doctor if you experience any swelling of the face, lips, or throat (angioedema).
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Losartan may cause dizziness or lightheadedness, especially when starting treatment or increasing the dose. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Follow a low-sodium diet and limit alcohol intake.
- Engage in regular physical activity as advised by your doctor.
- Avoid smoking and maintain a healthy weight.
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International brand names for this medicine. Click a brand to search for detailed information.
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