sb-omec
Generic Name
Omeprazole
Manufacturer
SB Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sb omec 40 mg capsule | ৳ 8.00 | N/A |
Description
Overview of the medicine
Omeprazole is a proton pump inhibitor used to reduce stomach acid production and treat conditions like gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
Duodenal ulcer: 20 mg once daily for 2-4 weeks. Gastric ulcer/GERD: 20-40 mg once daily for 4-8 weeks. Erosive esophagitis: 20 mg once daily for 4-8 weeks. Zollinger-Ellison Syndrome: Initial 60 mg once daily, adjusted based on response (up to 120 mg/day). H. pylori eradication: 20 mg twice daily with antibiotics for 7-14 days.
Elderly
No specific dose adjustment is generally required, but caution is advised due to potential for reduced hepatic function.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Take the capsule whole with water, preferably in the morning before a meal (e.g., 30-60 minutes before breakfast). Do not chew, crush, or open the capsule.
Mechanism of Action
Omeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase enzyme (the proton pump) on the secretory surface of gastric parietal cells. This action prevents the final step of acid production, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Acid inhibitory effect starts within 1-2 hours, maximum effect within 2 days of daily dosing.
Excretion
Approximately 77% of the dose is excreted in the urine and 18% in the feces (via biliary excretion) as metabolites.
Half life
Approximately 0.5 to 1.5 hours in healthy subjects, but the duration of acid suppression is much longer due to irreversible binding.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations occurring within 0.5 to 3.5 hours. Bioavailability is about 30-40% but increases with repeated dosing.
Metabolism
Extensively metabolized in the liver, primarily by the cytochrome P450 enzyme system, mainly CYP2C19 and CYP3A4.
Side Effects
Contraindications
- •Hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- •Concomitant use with nelfinavir (due to potential for reduced nelfinavir plasma concentrations).
Drug Interactions
Diazepam
May prolong the elimination half-life of diazepam.
Warfarin
Increased INR and prothrombin time in some patients. Monitor for increased bleeding risk.
Clopidogrel
Omeprazole can reduce the antiplatelet effect of clopidogrel by inhibiting its conversion to its active metabolite via CYP2C19. Avoid concomitant use.
Methotrexate
May increase serum levels of methotrexate, particularly with high-dose methotrexate. Monitor methotrexate levels.
Nelfinavir/Atazanavir
Omeprazole decreases plasma levels of these antivirals, reducing their efficacy. Concomitant use is contraindicated for nelfinavir and not recommended for atazanavir.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, headache, nausea, vomiting, tachycardia. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy: Category C. Use only if the potential benefit justifies the potential risk to the fetus. Lactation: Omeprazole is excreted in human milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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