Seebrox
Generic Name
Sevelamer Carbonate
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| seebrox 15 mg syrup | ৳ 40.00 | N/A |
Description
Overview of the medicine
Seebrox contains Sevelamer Carbonate, a non-calcium, non-aluminium phosphate binder, used to control serum phosphorus levels in adult patients with chronic kidney disease (CKD) on dialysis.
Uses & Indications
Dosage
Adults
Initial dose: 800 mg three times daily with meals. Adjust based on serum phosphorus levels (typically 800-1600 mg three times daily).
Elderly
No specific dosage adjustment needed for elderly patients.
Renal_impairment
Used for renal impairment patients, dose adjusted based on phosphorus levels.
How to Take
Orally, taken with meals. Tablets should be swallowed whole, not crushed, chewed, or broken.
Mechanism of Action
Sevelamer Carbonate is an orally administered, non-absorbable polymer that binds phosphate in the gastrointestinal tract, preventing its absorption into the bloodstream. It exchanges chloride for phosphate in the intestinal lumen.
Pharmacokinetics
Onset
Within days of starting therapy.
Excretion
Excreted unchanged in feces.
Half life
Not applicable (not absorbed).
Absorption
Not absorbed systemically.
Metabolism
Not metabolized.
Side Effects
Contraindications
- Hypersensitivity to sevelamer carbonate or any of its components.
- Hypophosphatemia.
- Bowel obstruction.
Drug Interactions
Ciprofloxacin
Decreased absorption of ciprofloxacin, administer at least 1 hour before or 3 hours after Sevelamer.
Levothyroxine
Reduced absorption, administer several hours apart.
Mycophenolate Mofetil
Reduced absorption, monitor drug levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Treatment should be supportive and symptomatic. Risk of hypophosphatemia.
Pregnancy & Lactation
Use only if clearly needed and the potential benefit outweighs the risk to the fetus or infant. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to sevelamer carbonate or any of its components.
- Hypophosphatemia.
- Bowel obstruction.
Drug Interactions
Ciprofloxacin
Decreased absorption of ciprofloxacin, administer at least 1 hour before or 3 hours after Sevelamer.
Levothyroxine
Reduced absorption, administer several hours apart.
Mycophenolate Mofetil
Reduced absorption, monitor drug levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Treatment should be supportive and symptomatic. Risk of hypophosphatemia.
Pregnancy & Lactation
Use only if clearly needed and the potential benefit outweighs the risk to the fetus or infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
Clinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of Sevelamer Carbonate in controlling hyperphosphatemia in CKD patients.
Lab Monitoring
- Serum phosphorus levels
- Serum calcium levels
- PTH (Parathyroid hormone) levels
Doctor Notes
- Regular monitoring of serum phosphate, calcium, and PTH levels is crucial.
- Advise patients on dietary phosphate restriction.
- Ensure proper administration with meals.
Patient Guidelines
- Take with meals.
- Swallow tablets whole.
- Do not take other medications at the same time without consulting your doctor.
Missed Dose Advice
If a dose is missed, skip the missed dose and take the next dose at the regular time with a meal. Do not double the dose.
Driving Precautions
Sevelamer is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Adhere to a low-phosphate diet as advised by your doctor or dietitian.
- Regular exercise and maintaining a healthy weight.
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Global Brand Names
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