Adults

Adults and children over 10 years or weighing more than 50 kg: 200 mg to 400 mg once daily or in two divided doses for 7-14 days depending on the infection.

Elderly

No specific dosage adjustment is required for the elderly unless there is severe renal impairment.

Renal_impairment

For creatinine clearance 21-60 mL/min, total daily dose should not exceed 300 mg. For creatinine clearance < 20 mL/min, total daily dose should not exceed 200 mg.

Onset

Peak plasma concentrations reached within 2-6 hours post-oral administration.

Excretion

Approximately 50% of an absorbed dose is excreted unchanged in the urine over 24 hours. The remainder is excreted by non-renal mechanisms, likely biliary excretion.

Half life

Average plasma half-life of 3-4 hours, which may be prolonged in patients with renal impairment.

Absorption

Approximately 40-50% absorbed orally. Food may delay absorption but does not significantly affect overall absorption.

Metabolism

Not extensively metabolized in the body; primarily excreted unchanged.

Probenecid

May increase Cefixime plasma levels by reducing renal tubular secretion.

Carbamazepine

Concurrent use with Cefixime has been reported to increase Carbamazepine levels.

Oral anticoagulants (e.g., Warfarin)

May increase prothrombin time and bleeding risk. Monitor INR carefully.