Selex
Generic Name
Cefixime 125 mg/5 ml Suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| selex 125 mg suspension | ৳ 82.00 | N/A |
Description
Overview of the medicine
Selex 125 mg Suspension contains Cefixime, a third-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections including those of the urinary tract, respiratory tract, ears, nose, throat, and skin.
Uses & Indications
Dosage
Adults
Typically 200 mg twice daily or 400 mg once daily. For children (6 months to 12 years), 8 mg/kg/day once daily or in two divided doses.
Elderly
Similar to adults, but dosage adjustment may be necessary in elderly patients with significant renal impairment.
Renal_impairment
Dose adjustment required. For creatinine clearance 21-60 mL/min, reduce to 75% of standard dose. For creatinine clearance <20 mL/min, reduce to 50% of standard dose.
How to Take
Selex suspension is for oral use. It can be taken with or without food. Shake the bottle well before each use. Use the provided measuring device to ensure accurate dosing. Complete the full course of treatment as prescribed by your doctor, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which inhibits the third and final stage of bacterial cell wall synthesis. This leads to the lysis and death of the bacterial cell.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved within 2-6 hours after administration.
Excretion
Primarily excreted unchanged in the urine (50-60%) and to a lesser extent in bile and feces.
Half life
About 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food may delay absorption but does not significantly affect the total amount absorbed.
Metabolism
Not extensively metabolized in the liver.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, other cephalosporin antibiotics, or any component of the formulation.
- History of severe hypersensitivity reaction to penicillin or other beta-lactam antibiotics (due to potential cross-reactivity).
Drug Interactions
Probenecid
Increases plasma concentration and prolongs the half-life of cefixime by decreasing renal excretion.
Carbamazepine
Concomitant use with cefixime has been reported to increase carbamazepine plasma concentrations.
Oral contraceptives
Some cephalosporins may reduce the effectiveness of oral contraceptives, although this is less documented for cefixime. Advise backup contraception.
Warfarin and other anticoagulants
May increase prothrombin time, potentially leading to increased bleeding risk. Monitor INR/PT carefully.
Storage
Store the dry powder below 30°C, protected from light and moisture. Keep out of reach of children. After reconstitution, store the suspension in a refrigerator (2-8°C) and do not freeze. Discard any unused portion after the specified period.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B: Animal reproduction studies have shown no risk, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Lactation: Cefixime is excreted in breast milk in small amounts. Use with caution in nursing mothers.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, other cephalosporin antibiotics, or any component of the formulation.
- History of severe hypersensitivity reaction to penicillin or other beta-lactam antibiotics (due to potential cross-reactivity).
Drug Interactions
Probenecid
Increases plasma concentration and prolongs the half-life of cefixime by decreasing renal excretion.
Carbamazepine
Concomitant use with cefixime has been reported to increase carbamazepine plasma concentrations.
Oral contraceptives
Some cephalosporins may reduce the effectiveness of oral contraceptives, although this is less documented for cefixime. Advise backup contraception.
Warfarin and other anticoagulants
May increase prothrombin time, potentially leading to increased bleeding risk. Monitor INR/PT carefully.
Storage
Store the dry powder below 30°C, protected from light and moisture. Keep out of reach of children. After reconstitution, store the suspension in a refrigerator (2-8°C) and do not freeze. Discard any unused portion after the specified period.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B: Animal reproduction studies have shown no risk, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Lactation: Cefixime is excreted in breast milk in small amounts. Use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: 24-36 months. Reconstituted suspension: 7-14 days when stored in a refrigerator (2-8°C).
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety for various bacterial infections. These trials typically involve studies on its pharmacokinetics, pharmacodynamics, dose-finding, and comparative efficacy against other antibiotics.
Lab Monitoring
- Liver function tests (LFTs) if prolonged treatment or pre-existing hepatic impairment.
- Renal function tests (e.g., creatinine clearance) in patients with renal impairment.
- Complete Blood Count (CBC) if prolonged use (rarely associated with hematological abnormalities).
Doctor Notes
- Cefixime is generally well-tolerated, but advise patients on potential for GI upset and allergic reactions.
- Emphasize the importance of completing the full course to prevent resistance.
- Consider renal function in elderly patients or those with pre-existing renal impairment for dose adjustment.
- Be aware of potential drug interactions, especially with anticoagulants.
Patient Guidelines
- Always complete the full course of antibiotics as prescribed, even if you feel better, to prevent the return of the infection and antibiotic resistance.
- Shake the suspension well before each use and use the provided measuring device for accurate dosing.
- Do not share this medicine with others, even if they have similar symptoms.
- Store the medicine as directed and keep out of reach of children.
- Report any severe or persistent side effects, especially severe diarrhea, to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Selex generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or other side effects that affect your concentration, avoid these activities.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infection.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea.
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