Selex capsules should be swallowed whole with a glass of water, with or without food. Taking it with food may help reduce stomach upset. Do not chew or crush the capsule.

Celecoxib selectively inhibits cyclooxygenase-2 (COX-2) enzyme. COX-2 is primarily responsible for the synthesis of prostaglandins involved in pain, inflammation, and fever. By inhibiting COX-2, celecoxib reduces the production of these inflammatory mediators.

• •Hypersensitivity to celecoxib, sulfonamides, or any component of the formulation
• •History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
• •Coronary artery bypass graft (CABG) surgery
• •Severe heart failure
• •Active peptic ulceration or gastrointestinal bleeding
• •Severe hepatic impairment

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management: Supportive care and symptomatic treatment. No specific antidote. Gastric decontamination (e.g., activated charcoal) may be considered within the first hour of ingestion.

Pregnancy: Avoid use in late pregnancy (third trimester) due to potential for premature closure of the fetal ductus arteriosus. Use earlier in pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Lactation: Not recommended during breastfeeding due to potential for serious adverse reactions in breastfed infants.