Selex
Generic Name
Celecoxib
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| selex 500 mg capsule | ৳ 12.43 | ৳ 124.30 |
Description
Overview of the medicine
Selex 500 mg Capsule contains Celecoxib, a selective COX-2 inhibitor, used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It works by reducing the production of prostaglandins, which are responsible for pain and inflammation.
Uses & Indications
Dosage
Adults
For osteoarthritis, 200 mg once daily or 100 mg twice daily. For rheumatoid arthritis, 100-200 mg twice daily. For acute pain or primary dysmenorrhea, an initial dose of 400 mg followed by 200 mg if needed on the first day, then 200 mg twice daily. A 500 mg capsule may be prescribed by a physician for specific acute conditions or severe pain for a short duration, but generally, the maximum daily dose for chronic use should not exceed 400 mg.
Elderly
Generally, no dosage adjustment is needed, but caution advised. For patients weighing less than 50 kg, start at the lowest recommended dose. Higher risks of adverse effects are possible.
Renal_impairment
Mild to moderate: No adjustment. Severe: Not recommended due to lack of adequate studies.
How to Take
Selex capsules should be swallowed whole with a glass of water, with or without food. Taking it with food may help reduce stomach upset. Do not chew or crush the capsule.
Mechanism of Action
Celecoxib selectively inhibits cyclooxygenase-2 (COX-2) enzyme. COX-2 is primarily responsible for the synthesis of prostaglandins involved in pain, inflammation, and fever. By inhibiting COX-2, celecoxib reduces the production of these inflammatory mediators.
Pharmacokinetics
Onset
Pain relief typically starts within 30-60 minutes.
Excretion
Mainly via feces (57%) and urine (27%), with less than 3% excreted unchanged.
Half life
Approximately 8-12 hours.
Absorption
Well absorbed orally; peak plasma concentrations reached in approximately 2-3 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C9.
Side Effects
Contraindications
- Hypersensitivity to celecoxib, sulfonamides, or any component of the formulation
- History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
- Coronary artery bypass graft (CABG) surgery
- Severe heart failure
- Active peptic ulceration or gastrointestinal bleeding
- Severe hepatic impairment
Drug Interactions
Lithium
Increased lithium plasma concentrations; monitor lithium levels.
Fluconazole
Significant increase in celecoxib plasma concentrations; reduce celecoxib dose.
Methotrexate
Increased methotrexate toxicity.
Warfarin and other anticoagulants
Increased risk of bleeding.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects.
ACE inhibitors, Angiotensin II Receptor Blockers (ARBs)
Reduced antihypertensive effect; increased risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management: Supportive care and symptomatic treatment. No specific antidote. Gastric decontamination (e.g., activated charcoal) may be considered within the first hour of ingestion.
Pregnancy & Lactation
Pregnancy: Avoid use in late pregnancy (third trimester) due to potential for premature closure of the fetal ductus arteriosus. Use earlier in pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Lactation: Not recommended during breastfeeding due to potential for serious adverse reactions in breastfed infants.
Side Effects
Contraindications
- Hypersensitivity to celecoxib, sulfonamides, or any component of the formulation
- History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
- Coronary artery bypass graft (CABG) surgery
- Severe heart failure
- Active peptic ulceration or gastrointestinal bleeding
- Severe hepatic impairment
Drug Interactions
Lithium
Increased lithium plasma concentrations; monitor lithium levels.
Fluconazole
Significant increase in celecoxib plasma concentrations; reduce celecoxib dose.
Methotrexate
Increased methotrexate toxicity.
Warfarin and other anticoagulants
Increased risk of bleeding.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects.
ACE inhibitors, Angiotensin II Receptor Blockers (ARBs)
Reduced antihypertensive effect; increased risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management: Supportive care and symptomatic treatment. No specific antidote. Gastric decontamination (e.g., activated charcoal) may be considered within the first hour of ingestion.
Pregnancy & Lactation
Pregnancy: Avoid use in late pregnancy (third trimester) due to potential for premature closure of the fetal ductus arteriosus. Use earlier in pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Lactation: Not recommended during breastfeeding due to potential for serious adverse reactions in breastfed infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available (original patent expired)
Clinical Trials
Extensive clinical trials have established the efficacy and safety of celecoxib in various inflammatory conditions. Ongoing research continues to explore its role in cancer prevention and other therapeutic areas, though its primary indications remain pain and inflammation management.
Lab Monitoring
- Monitor complete blood count (CBC) periodically, especially during long-term therapy
- Monitor liver function tests (LFTs) periodically
- Monitor renal function tests (RFTs) periodically
- Monitor blood pressure regularly
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Evaluate cardiovascular and gastrointestinal risk factors before initiating therapy and periodically thereafter.
- Monitor for signs and symptoms of GI bleeding and cardiovascular events.
- Consider alternative therapies in high-risk patients.
Patient Guidelines
- Take as directed by your doctor. Do not exceed the prescribed dose.
- Report any signs of gastrointestinal bleeding (black, tarry stools) or cardiovascular issues (chest pain, shortness of breath) immediately.
- Avoid taking other NSAIDs concurrently without consulting your doctor.
- Inform your doctor if you have a history of heart disease, stroke, or stomach ulcers.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or visual disturbances. If these occur, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy weight to reduce stress on joints.
- Engage in regular, low-impact exercise as tolerated (e.g., walking, swimming).
- Follow a balanced diet.
- Avoid smoking and excessive alcohol consumption, as these can exacerbate stomach issues and cardiovascular risks.
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