Sephar
Generic Name
Cephalexin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sephar 125 mg suspension | ৳ 80.00 | N/A |
Description
Overview of the medicine
Sephar 125 mg Suspension is an antibiotic medication containing Cephalexin, a first-generation cephalosporin. It is used to treat a wide range of bacterial infections including respiratory tract infections, ear infections, skin and soft tissue infections, and urinary tract infections.
Uses & Indications
Dosage
Adults
Not typically prescribed for adults in this strength. Adult dosage usually ranges from 250 mg to 1 g every 6 hours, depending on the infection.
Elderly
Dosage adjustment may be necessary for elderly patients with renal impairment. Consult a physician.
Renal_impairment
For patients with creatinine clearance < 40 mL/min, dosage intervals should be extended. e.g., 250 mg every 8-12 hours for mild impairment.
How to Take
Oral administration. Shake the bottle well before each use. Can be taken with or without food. Complete the full course of medication as prescribed, even if symptoms improve.
Mechanism of Action
Cephalexin is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Approximately 1 hour (oral)
Excretion
Mainly via the kidneys by glomerular filtration and tubular secretion. Approximately 70-90% is excreted unchanged in urine within 8 hours.
Half life
0.5 to 1.2 hours (normal renal function)
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract. Food may delay absorption but does not significantly reduce its extent.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cephalexin or other cephalosporins
- History of severe hypersensitivity reactions to penicillin (e.g., anaphylaxis)
Drug Interactions
Metformin
Co-administration with cephalexin may increase metformin plasma concentrations.
Probenecid
May increase cephalexin plasma concentrations and prolong its half-life by decreasing renal tubular secretion.
Live Typhoid Vaccine
Antibiotics may reduce the therapeutic effect of live typhoid vaccine. Administer at least 3 days apart.
Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect of warfarin and other oral anticoagulants, requiring INR monitoring.
Storage
Store dry powder below 30°C. Keep away from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard any unused portion after 14 days, or store at room temperature (below 30°C) and discard after 7 days, as per manufacturer's instructions.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric distress, diarrhea, and hematuria. Management is supportive; gastric lavage may be indicated, and hemodialysis may be helpful in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Cephalexin is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother. Generally considered safe, but use only if clearly needed and benefits outweigh risks.
Side Effects
Contraindications
- Hypersensitivity to cephalexin or other cephalosporins
- History of severe hypersensitivity reactions to penicillin (e.g., anaphylaxis)
Drug Interactions
Metformin
Co-administration with cephalexin may increase metformin plasma concentrations.
Probenecid
May increase cephalexin plasma concentrations and prolong its half-life by decreasing renal tubular secretion.
Live Typhoid Vaccine
Antibiotics may reduce the therapeutic effect of live typhoid vaccine. Administer at least 3 days apart.
Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect of warfarin and other oral anticoagulants, requiring INR monitoring.
Storage
Store dry powder below 30°C. Keep away from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard any unused portion after 14 days, or store at room temperature (below 30°C) and discard after 7 days, as per manufacturer's instructions.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric distress, diarrhea, and hematuria. Management is supportive; gastric lavage may be indicated, and hemodialysis may be helpful in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Cephalexin is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother. Generally considered safe, but use only if clearly needed and benefits outweigh risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years (unreconstituted powder). 7-14 days after reconstitution when stored at recommended temperature.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of cephalexin for various bacterial infections since its introduction.
Lab Monitoring
- Complete Blood Count (CBC) with differential if therapy is prolonged
- Renal function tests (e.g., serum creatinine, BUN) in patients with pre-existing renal impairment or during prolonged therapy
Doctor Notes
- Advise parents on proper measurement and administration of suspension.
- Emphasize completing the full antibiotic course to prevent resistance.
- Monitor for signs of allergic reactions, especially in patients with penicillin allergy.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Complete the full course of treatment, even if you feel better.
- Shake the suspension well before each use.
- Store in a cool, dry place away from direct sunlight.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cephalexin generally does not impair the ability to drive or operate machinery. However, if you experience side effects like dizziness, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Eat a balanced diet. If diarrhea occurs, avoid dairy products and sugary drinks for a short period.
- Practice good hygiene to prevent spread of infection.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Sephar Brand
Other medicines available under the same brand name
