Sepra-S
Generic Name
Sepra-S
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sepra s 500 mg capsule | ৳ 15.00 | N/A |
| sepra s 125 mg suspension | ৳ 86.00 | N/A |
Description
Overview of the medicine
Sepra-S contains Esomeprazole, a proton pump inhibitor used to reduce stomach acid production. It treats conditions like GERD, ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
For GERD: 20 mg or 40 mg once daily for 4-8 weeks. For H. pylori eradication: 20 mg or 40 mg twice daily for 7-14 days.
Elderly
No dose adjustment generally required, but caution in patients with severe hepatic impairment.
Renal_impairment
No dose adjustment necessary for renal impairment.
How to Take
Take at least one hour before a meal. Swallow capsules/tablets whole; do not chew or crush. For patients with difficulty swallowing, capsules can be opened and the contents mixed with a small amount of water or soft food and consumed immediately.
Mechanism of Action
Esomeprazole selectively inhibits the H+/K+-ATPase enzyme system (the 'proton pump') in the gastric parietal cells, thereby blocking the final step of acid secretion.
Pharmacokinetics
Onset
Acid-suppressing effect begins within 1 hour.
Excretion
Mainly excreted in urine (80%) and feces (20%) as metabolites.
Half life
Approximately 1.5 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver via CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Known hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Increased INR and prothrombin time; monitor patients closely.
Tacrolimus
Increased serum levels of tacrolimus; monitor concentrations.
Clopidogrel
Reduced antiplatelet effect of clopidogrel; generally avoid concomitant use.
Methotrexate
Increased levels of methotrexate; consider temporary withdrawal of PPI.
CYP2C19 inhibitors/inducers
Potential for altered esomeprazole metabolism.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and include gastrointestinal disturbances and weakness. Treatment is symptomatic and supportive. Esomeprazole is extensively protein-bound and not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. It is unknown if Esomeprazole is excreted in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Known hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Increased INR and prothrombin time; monitor patients closely.
Tacrolimus
Increased serum levels of tacrolimus; monitor concentrations.
Clopidogrel
Reduced antiplatelet effect of clopidogrel; generally avoid concomitant use.
Methotrexate
Increased levels of methotrexate; consider temporary withdrawal of PPI.
CYP2C19 inhibitors/inducers
Potential for altered esomeprazole metabolism.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and include gastrointestinal disturbances and weakness. Treatment is symptomatic and supportive. Esomeprazole is extensively protein-bound and not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. It is unknown if Esomeprazole is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by regulatory authorities (e.g., DGDA, FDA)
Patent Status
Patent expired for generic Esomeprazole
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated Esomeprazole's efficacy and safety in various acid-related disorders. Studies confirm its superior acid suppression compared to other PPIs in some cases.
Lab Monitoring
- No routine lab monitoring required for most patients. For long-term use (over 1 year), magnesium levels may need monitoring due to risk of hypomagnesemia.
- Consider Vitamin B12 levels in patients with risk factors for deficiency on long-term therapy.
Doctor Notes
- Counsel patients on potential long-term risks with chronic PPI use.
- Consider lowest effective dose and shortest duration for treatment.
- Regularly review the need for continued PPI therapy.
- Be aware of drug interactions, especially with clopidogrel and methotrexate.
Patient Guidelines
- Take as directed by your doctor, preferably before your first meal of the day.
- Do not crush, chew, or break the capsule/tablet.
- Inform your doctor about all other medications you are taking.
- Seek medical advice if symptoms do not improve or worsen.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Sepra-S is generally not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness or blurred vision occur, patients should avoid such activities.
Lifestyle Advice
- Avoid spicy foods, caffeine, alcohol, and fatty meals.
- Eat smaller, more frequent meals.
- Elevate the head of your bed to reduce nighttime reflux.
- Quit smoking.
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