Serolux
Generic Name
Serolux
Manufacturer
MediCare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| serolux 100 mg tablet | ৳ 11.20 | ৳ 112.00 |
Description
Overview of the medicine
Serolux 100 mg Tablet is an antidepressant belonging to the Selective Serotonin Reuptake Inhibitor (SSRI) class. It is primarily used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, and social anxiety disorder. It helps to restore the balance of a certain natural substance (serotonin) in the brain.
Uses & Indications
Dosage
Adults
Initial dose 50 mg once daily, may be increased to 100 mg once daily after several weeks. Maximum dose 200 mg/day.
Elderly
Initial dose 25 mg once daily, may be gradually increased. Lower doses may be considered due to potential for increased sensitivity.
Renal_impairment
No dosage adjustment generally required for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Take orally, once daily, with or without food. It is recommended to take it at the same time each day.
Mechanism of Action
Serolux selectively inhibits the reuptake of serotonin (5-HT) into the presynaptic neuron, thereby potentiating serotonergic activity in the central nervous system. This leads to an increase in serotonin concentration in the synaptic cleft, improving mood and reducing anxiety.
Pharmacokinetics
Onset
Initial therapeutic effects may be observed within 2-4 weeks; full effects within 6-8 weeks.
Excretion
Excreted primarily in feces (approximately 60%) and urine (approximately 35%), mainly as metabolites.
Half life
Approximately 24-26 hours, with active metabolites having a longer half-life.
Absorption
Well absorbed orally; peak plasma concentrations achieved within 4-8 hours. Food may slightly increase absorption.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (primarily CYP2C19 and CYP2B6), with first-pass metabolism.
Side Effects
Contraindications
- Hypersensitivity to Serolux or any excipients
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI
- Concomitant use with pimozide
Drug Interactions
MAOIs
Potentially fatal serotonin syndrome. Avoid concomitant use.
Pimozide
Increased pimozide levels and potential for QT prolongation. Contraindicated.
Triptans
Increased risk of serotonin syndrome.
Warfarin
May increase prothrombin time; monitor INR.
NSAIDs/Aspirin
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include somnolence, vomiting, tachycardia, tremor, agitation, dizziness, and rarely coma. Management involves supportive care and symptomatic treatment. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if potential benefit outweighs potential risk to the fetus. Serolux is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Serolux or any excipients
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI
- Concomitant use with pimozide
Drug Interactions
MAOIs
Potentially fatal serotonin syndrome. Avoid concomitant use.
Pimozide
Increased pimozide levels and potential for QT prolongation. Contraindicated.
Triptans
Increased risk of serotonin syndrome.
Warfarin
May increase prothrombin time; monitor INR.
NSAIDs/Aspirin
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include somnolence, vomiting, tachycardia, tremor, agitation, dizziness, and rarely coma. Management involves supportive care and symptomatic treatment. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if potential benefit outweighs potential risk to the fetus. Serolux is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by Regulatory Authority
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Serolux in its approved indications. Ongoing post-marketing surveillance continues to monitor its effects.
Lab Monitoring
- Baseline and periodic monitoring of liver function tests (LFTs) in patients with hepatic impairment.
- Monitor serum sodium, especially in elderly patients or those on diuretics.
Doctor Notes
- Educate patients about the delayed onset of action and the importance of adherence.
- Monitor for signs of worsening depression or suicidality, especially at the start of treatment or after dose changes.
- Advise patients on potential drug interactions and side effects.
Patient Guidelines
- Take Serolux exactly as prescribed by your doctor.
- Do not stop taking Serolux suddenly without consulting your doctor, as this can lead to withdrawal symptoms.
- It may take several weeks to feel the full benefits of this medicine.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose to catch up.
Driving Precautions
Serolux may cause dizziness, drowsiness, or visual disturbances. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a balanced diet and regular exercise.
- Practice stress-reducing techniques like meditation or yoga.
- Limit alcohol consumption.
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Global Brand Names
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