Sertlin
Generic Name
Sertlin 50 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sertlin 50 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Sertlin 50 mg Tablet contains Sertraline, a selective serotonin reuptake inhibitor (SSRI) used to treat various mental health conditions including depression, obsessive-compulsive disorder, panic disorder, and social anxiety disorder. It works by increasing the levels of serotonin in the brain, which helps to improve mood and reduce anxiety.
Uses & Indications
Dosage
Adults
Initial dose is 50 mg once daily for MDD and OCD. For PD, PTSD, SAD, PMDD, initial dose is 25 mg once daily, increased to 50 mg after one week. Maximum dose for all indications is 200 mg once daily.
Elderly
Lower initial doses and slower titration may be considered for elderly patients due to potentially increased sensitivity.
Renal_impairment
No dosage adjustment is generally required for mild to moderate renal impairment. Caution is advised in severe renal impairment.
How to Take
Sertlin 50 mg Tablet should be taken orally once daily, either in the morning or evening, with or without food. It is recommended to take it at the same time each day.
Mechanism of Action
Sertraline selectively inhibits the reuptake of serotonin (5-HT) by the presynaptic neuron, thereby increasing the concentration of serotonin in the synaptic cleft and enhancing serotonergic neurotransmission. It has minimal effects on norepinephrine and dopamine reuptake.
Pharmacokinetics
Onset
Therapeutic effects typically begin within 2 to 4 weeks of treatment, though some symptom improvement may be seen earlier.
Excretion
Approximately 40-45% excreted in feces and 40-45% in urine, predominantly as metabolites. Less than 2% is excreted unchanged in urine.
Half life
Approximately 26 hours for sertraline and 62-104 hours for its active metabolite, N-desmethylsertraline.
Absorption
Well absorbed after oral administration, with peak plasma concentrations occurring 4.5 to 8.4 hours post-dose. Food slightly increases the absorption rate and AUC.
Metabolism
Extensively metabolized in the liver, primarily via CYP2D6, CYP2C19, CYP2B6, and CYP3A4, to its major inactive metabolite, N-desmethylsertraline.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
- Concomitant use with pimozide.
- Known hypersensitivity to sertraline or any component of the formulation.
Drug Interactions
MAOIs
Concurrent use may lead to serotonin syndrome, which can be life-threatening.
Pimozide
Increased pimozide levels and cardiotoxicity; contraindicated.
Warfarin
Increased prothrombin time/INR, potentially leading to increased bleeding risk.
CNS Depressants and Alcohol
May potentiate the effects of alcohol and other CNS depressants.
Other Serotonergic Drugs (e.g., Triptans, Fentanyl, Tramadol, Lithium, St. John's Wort)
Increased risk of serotonin syndrome.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, vomiting, tachycardia, tremor, agitation, dizziness, and serotonin syndrome. Management involves supportive and symptomatic treatment, maintaining an open airway, monitoring cardiac and vital signs. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Sertraline should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human breast milk in small amounts; caution should be exercised when administering to a nursing mother.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
- Concomitant use with pimozide.
- Known hypersensitivity to sertraline or any component of the formulation.
Drug Interactions
MAOIs
Concurrent use may lead to serotonin syndrome, which can be life-threatening.
Pimozide
Increased pimozide levels and cardiotoxicity; contraindicated.
Warfarin
Increased prothrombin time/INR, potentially leading to increased bleeding risk.
CNS Depressants and Alcohol
May potentiate the effects of alcohol and other CNS depressants.
Other Serotonergic Drugs (e.g., Triptans, Fentanyl, Tramadol, Lithium, St. John's Wort)
Increased risk of serotonin syndrome.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, vomiting, tachycardia, tremor, agitation, dizziness, and serotonin syndrome. Management involves supportive and symptomatic treatment, maintaining an open airway, monitoring cardiac and vital signs. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Sertraline should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human breast milk in small amounts; caution should be exercised when administering to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 2-3 years from the date of manufacture when stored properly.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Sertraline has undergone extensive clinical trials supporting its efficacy and safety for various psychiatric conditions. Ongoing post-marketing surveillance and new trials continue to explore its uses and refine safety profiles.
Lab Monitoring
- Baseline and periodic monitoring of liver function tests in patients with hepatic impairment.
- Monitoring of serum sodium in elderly or volume-depleted patients, or those on diuretics, due to risk of hyponatremia.
Doctor Notes
- Emphasize the importance of gradual discontinuation to avoid withdrawal symptoms.
- Monitor patients, especially young adults, for worsening depression or emergence of suicidal ideation.
- Educate patients on potential side effects, including sexual dysfunction, and strategies to manage them.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor; do not stop abruptly without consulting your doctor.
- It may take 2-4 weeks to experience the full therapeutic effects.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Be aware of the risk of suicidal thoughts, especially at the beginning of treatment or when the dose is changed, and report any such thoughts to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Sertraline may cause drowsiness, dizziness, or blurred vision. Patients should be cautious when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Avoid alcohol consumption while taking sertraline, as it may enhance CNS depressant effects.
- Report any unusual symptoms or side effects to your doctor.
- Maintain a healthy lifestyle with regular exercise and a balanced diet.
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