Sigtil
Generic Name
Sitagliptin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sigtil 100 mg tablet | ৳ 28.00 | ৳ 280.00 |
Description
Overview of the medicine
Sigtil 100 mg tablet contains Sitagliptin, an oral antidiabetic drug used to improve blood sugar control in adults with type 2 diabetes mellitus. It belongs to a class of medicines called DPP-4 inhibitors.
Uses & Indications
Dosage
Adults
The recommended dose is 100 mg once daily. Can be taken with or without food.
Elderly
No dose adjustment required based on age; however, renal function should be assessed before initiating and periodically during treatment.
Renal_impairment
For moderate renal impairment (CrCl ≥30 to <50 mL/min): 50 mg once daily. For severe renal impairment (CrCl <30 mL/min) or end-stage renal disease requiring dialysis: 25 mg once daily.
How to Take
Take the tablet orally once daily, with or without food, as directed by your doctor.
Mechanism of Action
Sitagliptin selectively inhibits the enzyme dipeptidyl peptidase-4 (DPP-4), which is responsible for inactivating the incretin hormones GLP-1 and GIP. By inhibiting DPP-4, Sitagliptin increases the levels of active incretin hormones, leading to enhanced glucose-dependent insulin secretion and suppressed glucagon secretion from the pancreas.
Pharmacokinetics
Onset
Within 24 hours of administration.
Excretion
Primarily excreted unchanged in the urine (approximately 79%).
Half life
Approximately 12.4 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations (Tmax) typically reached in 1-4 hours. Absolute bioavailability is approximately 87%.
Metabolism
Limited metabolism, primarily by CYP3A4 and to a lesser extent by CYP2C8.
Side Effects
Contraindications
- Hypersensitivity to sitagliptin or any component of the formulation.
- Patients with type 1 diabetes or diabetic ketoacidosis.
Drug Interactions
Digoxin
Increased plasma concentrations of digoxin were observed; monitor digoxin levels if co-administered.
Cyclosporine
No clinically meaningful interaction observed.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, symptomatic and supportive treatment should be initiated. Sitagliptin is modestly dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. It is not known whether sitagliptin is excreted in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to sitagliptin or any component of the formulation.
- Patients with type 1 diabetes or diabetic ketoacidosis.
Drug Interactions
Digoxin
Increased plasma concentrations of digoxin were observed; monitor digoxin levels if co-administered.
Cyclosporine
No clinically meaningful interaction observed.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, symptomatic and supportive treatment should be initiated. Sitagliptin is modestly dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. It is not known whether sitagliptin is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Patent expired in many regions; generic versions available
Clinical Trials
Sitagliptin has been evaluated in numerous clinical trials demonstrating its efficacy and safety profile in improving glycemic control in patients with type 2 diabetes mellitus, both as monotherapy and in combination with other antidiabetic agents.
Lab Monitoring
- Renal function (e.g., serum creatinine, eGFR) should be assessed before starting therapy and periodically thereafter.
- HbA1c and blood glucose levels should be monitored regularly to assess glycemic control.
Doctor Notes
- Counsel patients on symptoms of pancreatitis (persistent severe abdominal pain) and advise seeking immediate medical attention if they occur.
- Monitor renal function before and periodically during treatment, especially in elderly and renally impaired patients, and adjust dose as needed.
- Be aware of potential for hypoglycemia when used in combination with insulin or sulfonylureas.
Patient Guidelines
- Take Sigtil 100 mg tablet exactly as prescribed by your doctor.
- Do not stop taking this medicine without consulting your doctor.
- Report any unusual or severe symptoms, especially persistent severe abdominal pain (possible pancreatitis) or allergic reactions.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose.
Driving Precautions
Sigtil 100 mg tablet is unlikely to affect your ability to drive or operate machinery. However, if used in combination with a sulfonylurea or insulin, the risk of hypoglycemia may increase, which could impair driving ability. Be aware of hypoglycemia symptoms.
Lifestyle Advice
- Maintain a healthy and balanced diet as recommended by your healthcare provider.
- Engage in regular physical activity to help manage blood sugar levels.
- Monitor your blood glucose levels regularly as instructed by your doctor.
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