Sigtil
Generic Name
Sitagliptin 50 mg tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sigtil 50 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Sigtil 50 mg Tablet contains Sitagliptin, an oral antidiabetic medicine used to lower blood sugar levels in adults with type 2 diabetes mellitus.
Uses & Indications
Dosage
Adults
Usually 100 mg once daily. For moderate renal impairment (CrCl ≥30 to <50 mL/min), 50 mg once daily is recommended. For severe renal impairment (CrCl <30 mL/min) or ESRD requiring dialysis, 25 mg once daily is recommended.
Elderly
No dose adjustment generally required based on age alone; however, renal function should be assessed.
Renal_impairment
Moderate renal impairment (CrCl ≥30 to <50 mL/min): 50 mg once daily. Severe renal impairment (CrCl <30 mL/min) or ESRD requiring dialysis: 25 mg once daily.
How to Take
Administer orally once daily, with or without food.
Mechanism of Action
Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances the activity of incretin hormones (GLP-1 and GIP), leading to increased insulin synthesis and release from pancreatic beta cells and decreased glucagon secretion from alpha cells, thereby lowering blood glucose.
Pharmacokinetics
Onset
Peak plasma concentrations reached in 1-4 hours.
Excretion
Primarily renal (79% unchanged), with some fecal excretion.
Half life
Approximately 12.4 hours.
Absorption
Rapidly absorbed, bioavailability approximately 87%. Peak plasma concentrations reached in 1-4 hours.
Metabolism
Minimally metabolized, primarily by CYP3A4 and to a lesser extent by CYP2C8.
Side Effects
Contraindications
- Hypersensitivity to sitagliptin or any component of the formulation.
- Patients with a history of serious hypersensitivity reaction to sitagliptin (e.g., anaphylaxis, angioedema).
Drug Interactions
Digoxin
Monitor digoxin levels if coadministered, as sitagliptin may slightly increase digoxin plasma concentrations.
Cyclosporine
Minimal interaction, no significant dose adjustment needed.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
In case of overdose, symptomatic and supportive treatment is recommended. Sitagliptin is modestly dialyzable.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and potential benefits outweigh risks. Caution is advised during lactation, as sitagliptin is excreted in animal milk.
Side Effects
Contraindications
- Hypersensitivity to sitagliptin or any component of the formulation.
- Patients with a history of serious hypersensitivity reaction to sitagliptin (e.g., anaphylaxis, angioedema).
Drug Interactions
Digoxin
Monitor digoxin levels if coadministered, as sitagliptin may slightly increase digoxin plasma concentrations.
Cyclosporine
Minimal interaction, no significant dose adjustment needed.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
In case of overdose, symptomatic and supportive treatment is recommended. Sitagliptin is modestly dialyzable.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and potential benefits outweigh risks. Caution is advised during lactation, as sitagliptin is excreted in animal milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, as indicated on the packaging.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Patent expired for generic versions, innovator patent held by Merck
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety in patients with type 2 diabetes, both as monotherapy and in combination with other agents, showing significant reduction in HbA1c.
Lab Monitoring
- HbA1c levels (regularly to assess glycemic control).
- Renal function (e.g., CrCl) prior to initiation and periodically thereafter.
Doctor Notes
- Consider dose adjustment for renal impairment based on CrCl.
- Counsel patients on signs of pancreatitis (e.g., persistent severe abdominal pain radiating to the back) and hypersensitivity reactions (e.g., rash, angioedema).
- Advise patients about the importance of diet and exercise in diabetes management.
Patient Guidelines
- Take as directed by your doctor, usually once daily.
- Do not stop taking without consulting your doctor.
- Maintain diet and exercise regimen recommended by your doctor.
- Report any unusual side effects, especially severe joint pain or signs of pancreatitis (e.g., persistent severe abdominal pain).
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Generally no effect on ability to drive or operate machinery. However, if symptoms of hypoglycemia (e.g., dizziness) occur, caution is advised, especially if used with insulin or sulfonylureas.
Lifestyle Advice
- Follow a healthy diet plan to manage blood sugar.
- Engage in regular physical activity as advised by your healthcare provider.
- Monitor blood sugar levels regularly as instructed.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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