Silclog
Generic Name
Cilostazol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| silclog 75 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Silclog (Cilostazol) is a medication used to reduce the symptoms of intermittent claudication, which is leg pain caused by too little blood flow during exercise. It works by improving blood flow to the legs.
Uses & Indications
Dosage
Adults
The recommended dosage is 100 mg twice daily, taken at least 30 minutes before or 2 hours after breakfast and dinner. A 50 mg twice daily dose may be considered in patients receiving concomitant inhibitors of CYP3A4 or CYP2C19.
Elderly
No specific dosage adjustment is required based on age, but caution is advised due to potential for increased sensitivity.
Renal_impairment
Use with caution in severe renal impairment (creatinine clearance ≤25 mL/min); dosage reduction may be necessary.
How to Take
Take orally with water, at least 30 minutes before or 2 hours after breakfast and dinner. Do not crush or chew the tablet.
Mechanism of Action
Cilostazol is a phosphodiesterase-3 (PDE3) inhibitor that suppresses platelet aggregation and causes vasodilation. It increases intracellular cyclic AMP (cAMP) in platelets and vascular smooth muscle, leading to inhibition of platelet aggregation and vasodilation.
Pharmacokinetics
Onset
Clinical effects may take 2-4 weeks to be evident, maximal effects in 12 weeks.
Excretion
Excreted primarily in urine (74%) and feces (20%) as metabolites.
Half life
Approximately 11-13 hours (for cilostazol and its active metabolites).
Absorption
Rapidly absorbed after oral administration. High-fat meals can increase absorption.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4 and CYP2C19, to two active metabolites.
Side Effects
Contraindications
- Congestive heart failure of any severity (Black Box Warning).
- Known hypersensitivity to cilostazol or any component of the formulation.
- Hemostatic disorders or active pathological bleeding (e.g., active peptic ulceration, intracranial hemorrhage).
- Patients with severe kidney or liver impairment.
Drug Interactions
Anticoagulants (e.g., warfarin, heparin)
Increased risk of bleeding.
Antiplatelet agents (e.g., aspirin, clopidogrel)
Increased risk of bleeding.
CYP2C19 inhibitors (e.g., omeprazole, fluconazole)
May increase cilostazol levels; consider dose reduction.
CYP3A4 inhibitors (e.g., erythromycin, diltiazem, ketoconazole)
May increase cilostazol levels; consider dose reduction.
Storage
Store in a cool, dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe headache, diarrhea, tachycardia, and palpitations. Treatment is primarily supportive. Gastric lavage or activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during lactation as it is unknown if cilostazol is excreted in human milk.
Side Effects
Contraindications
- Congestive heart failure of any severity (Black Box Warning).
- Known hypersensitivity to cilostazol or any component of the formulation.
- Hemostatic disorders or active pathological bleeding (e.g., active peptic ulceration, intracranial hemorrhage).
- Patients with severe kidney or liver impairment.
Drug Interactions
Anticoagulants (e.g., warfarin, heparin)
Increased risk of bleeding.
Antiplatelet agents (e.g., aspirin, clopidogrel)
Increased risk of bleeding.
CYP2C19 inhibitors (e.g., omeprazole, fluconazole)
May increase cilostazol levels; consider dose reduction.
CYP3A4 inhibitors (e.g., erythromycin, diltiazem, ketoconazole)
May increase cilostazol levels; consider dose reduction.
Storage
Store in a cool, dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe headache, diarrhea, tachycardia, and palpitations. Treatment is primarily supportive. Gastric lavage or activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during lactation as it is unknown if cilostazol is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies and hospitals
Approval Status
DGDA approved
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials have demonstrated the efficacy of cilostazol in increasing walking distance and improving quality of life for patients with intermittent claudication.
Lab Monitoring
- Monitor for signs of bleeding, especially if co-administered with other antiplatelet or anticoagulant agents. Routine laboratory monitoring is generally not required.
Doctor Notes
- Strictly contraindicated in heart failure. Monitor for bleeding, especially in patients on concomitant antiplatelets/anticoagulants. Advise patients on optimal administration (before/after meals).
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Avoid grapefruit juice while on this medication.
- Inform your doctor about any bleeding or unusual bruising.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Silclog may cause dizziness. If you experience dizziness, avoid driving or operating machinery.
Lifestyle Advice
- Quit smoking as it is a major risk factor for peripheral artery disease.
- Engage in regular, guided exercise programs as recommended by your doctor.
- Manage other risk factors such as high blood pressure, diabetes, and high cholesterol.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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