Silofast
Generic Name
Silodosin
Manufacturer
Cipla Ltd.
Country
India
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| silofast 8 mg capsule | ৳ 17.00 | ৳ 170.00 |
Description
Overview of the medicine
Silofast 8 mg capsule is used to treat the symptoms of benign prostatic hyperplasia (BPH) in men. It helps to relieve symptoms like difficulty in urination, frequent urination, and weak stream by relaxing the muscles in the prostate and bladder.
Uses & Indications
Dosage
Adults
The recommended dose is 8 mg once daily with a meal. For patients with moderate renal impairment (CrCl 30-50 mL/min), the starting dose is 4 mg once daily. For severe renal impairment (CrCl < 30 mL/min), use is not recommended.
Elderly
No specific dose adjustment is required based on age alone, but renal function should be considered.
Renal_impairment
Moderate renal impairment (CrCl 30-50 mL/min): 4 mg once daily. Severe renal impairment (CrCl < 30 mL/min): Not recommended.
How to Take
Take Silofast 8 mg capsule orally once daily with a meal, preferably at the same time each day. Swallow the capsule whole; do not crush, chew, or open it.
Mechanism of Action
Silodosin is a selective antagonist of alpha-1A adrenoceptors. These receptors are predominantly located in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. By blocking these receptors, silodosin causes the smooth muscle in these tissues to relax, thereby reducing the outflow obstruction and improving urine flow in patients with BPH.
Pharmacokinetics
Onset
Symptom improvement can be observed within a week, but maximum effect may take several weeks.
Excretion
Mainly excreted in urine (approximately 33%) and feces (approximately 55%) as metabolites and unchanged drug.
Half life
Approximately 13 hours.
Absorption
Rapidly absorbed after oral administration, reaching peak plasma concentrations within 2.5 hours. Bioavailability is approximately 32%. Absorption is increased when taken with food.
Metabolism
Extensively metabolized primarily by CYP3A4, alcohol dehydrogenase, and UGT2B7. The major active metabolite is KMD-3213G.
Side Effects
Contraindications
- •Hypersensitivity to silodosin or any component of the formulation.
- •Severe renal impairment (CrCl < 30 mL/min).
- •Severe hepatic impairment.
- •Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir).
Drug Interactions
Alpha-blockers
Concomitant use with other alpha-blockers is not recommended due to the potential for increased hypotensive effects.
CYP3A4 Inducers
Strong CYP3A4 inducers (e.g., rifampicin, phenytoin) may decrease silodosin plasma concentrations.
CYP3A4 Inhibitors
Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir) can significantly increase silodosin exposure, leading to increased risk of side effects. Concomitant use is contraindicated. Moderate CYP3A4 inhibitors (e.g., diltiazem) should be used with caution, and a lower dose of silodosin (4 mg) may be considered.
Antihypertensive drugs
May increase the risk of orthostatic hypotension when used concurrently with other antihypertensive agents.
PDE5 Inhibitors (e.g., sildenafil, tadalafil)
Concurrent use may lead to additive hypotensive effects, particularly orthostatic hypotension. Use with caution, starting with the lowest dose of PDE5 inhibitor.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Overdose of silodosin can lead to severe orthostatic hypotension and compensatory tachycardia. Management should involve supportive care and symptomatic treatment. Lying down can help to restore blood pressure. If necessary, vasopressors and fluid expanders can be administered. Dialysis is unlikely to be beneficial due to high protein binding.
Pregnancy & Lactation
Silofast is not indicated for use in women. There is no information on its use in pregnant or lactating women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved (in various countries)
Patent Status
Off-patent (generic versions available)
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
