Silpol
Generic Name
Paracetamol 120 mg/5 ml Suspension
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| silpol 120 mg suspension | ৳ 35.00 | N/A |
Description
Overview of the medicine
Silpol 120 mg Suspension is a common pain reliever and fever reducer for children. It contains Paracetamol (Acetaminophen) as its active ingredient and is used to treat mild to moderate pain and fever.
Uses & Indications
Dosage
Adults
Not typically used for adults in this strength; refer to higher strength formulations.
Elderly
Not typically used for elderly in this strength; refer to higher strength formulations.
Renal_impairment
Dosage adjustment may be necessary in severe renal impairment. Consult physician.
How to Take
Administer orally. Shake the bottle well before use. Use a measuring spoon or oral syringe to ensure accurate dosing. Can be taken with or without food.
Mechanism of Action
Paracetamol's exact mechanism is not fully understood, but it is believed to act primarily by inhibiting prostaglandin synthesis in the central nervous system, leading to its analgesic and antipyretic effects. It has weak anti-inflammatory effects peripherally.
Pharmacokinetics
Onset
30-60 minutes for analgesic/antipyretic effect.
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
1-4 hours (typically 2-3 hours) in adults; slightly longer in neonates, shorter in children.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 10-60 minutes after oral administration.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation. A small amount is metabolized by cytochrome P450 to a highly reactive intermediate (NAPQI), which is normally detoxified by glutathione.
Side Effects
Contraindications
- •Known hypersensitivity to Paracetamol or any other component of the formulation.
- •Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Increased risk of hepatotoxicity with chronic excessive alcohol intake.
Warfarin
May enhance anticoagulant effect, increasing risk of bleeding with prolonged high-dose use.
Cholestyramine
Reduces paracetamol absorption if taken within one hour.
Metoclopramide, Domperidone
Increases paracetamol absorption rate.
Storage
Store below 30°C in a dry place, away from light. Do not freeze.
Overdose
Overdose of Paracetamol can cause severe, potentially fatal liver damage. Symptoms may include nausea, vomiting, abdominal pain, and sweating, which may appear 24-48 hours after ingestion. Seek immediate medical attention. Treatment includes gastric lavage, activated charcoal, and N-acetylcysteine (NAC) administration.
Pregnancy & Lactation
Paracetamol is generally considered safe during pregnancy and lactation when used at recommended doses for the shortest possible duration. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Pharmacies, drugstores
Approval Status
Approved by health authorities
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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