Sinacet
Generic Name
Sinacetin 25 mg Oral Solution
Manufacturer
MediPharm Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sinacet 25 mg oral solution | ৳ 50.00 | N/A |
Description
Overview of the medicine
Sinacet 25 mg Oral Solution is an anti-inflammatory, analgesic, and antipyretic medicine used for the relief of pain, fever, and inflammation. It belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs).
Uses & Indications
Dosage
Adults
Typically 50-100 mg (10-20 mL) three times daily, or as directed by physician. Maximum daily dose 300 mg.
Elderly
Lower doses may be required; monitor for adverse effects.
Renal_impairment
Use with caution; dose adjustment may be necessary based on creatinine clearance.
How to Take
Administer orally. Can be taken with or without food. To minimize gastric irritation, it is often recommended to take it with food or milk.
Mechanism of Action
Sinacetin, the active ingredient, works by inhibiting the activity of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. This leads to a reduction in the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Mainly excreted via urine as metabolites.
Half life
Approximately 2-4 hours.
Absorption
Rapidly and extensively absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to sinacetin or other NSAIDs (e.g., aspirin-induced asthma)
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors/ARBs
Increased risk of renal impairment and reduced antihypertensive effects.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and occasionally more severe effects like gastrointestinal bleeding, acute renal failure, or respiratory depression. Management involves symptomatic and supportive treatment; gastric lavage or activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Avoid use in the third trimester of pregnancy due to potential risk of premature closure of the ductus arteriosus and renal dysfunction in the fetus. Use with caution during lactation; small amounts may pass into breast milk.
Side Effects
Contraindications
- Known hypersensitivity to sinacetin or other NSAIDs (e.g., aspirin-induced asthma)
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors/ARBs
Increased risk of renal impairment and reduced antihypertensive effects.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and occasionally more severe effects like gastrointestinal bleeding, acute renal failure, or respiratory depression. Management involves symptomatic and supportive treatment; gastric lavage or activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Avoid use in the third trimester of pregnancy due to potential risk of premature closure of the ductus arteriosus and renal dysfunction in the fetus. Use with caution during lactation; small amounts may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Clinical trials demonstrated efficacy in pain and fever reduction across various patient populations, with a safety profile consistent with other NSAIDs.
Lab Monitoring
- Complete blood count (CBC)
- Renal function tests (e.g., serum creatinine, BUN)
- Liver function tests (e.g., ALT, AST)
Doctor Notes
- Assess patient's cardiovascular and gastrointestinal risk factors before prescribing.
- Use the lowest effective dose for the shortest possible duration.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Report any unusual bleeding, persistent stomach pain, or dark stools immediately.
- Avoid alcohol while taking this medicine.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness; caution should be exercised when driving or operating machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid prolonged exposure to sunlight as NSAIDs can increase photosensitivity.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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