Sinacet
Generic Name
Sinacet (Hypothetical Anti-inflammatory)
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sinacet 5 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Sinacet 5 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is commonly prescribed for conditions such as osteoarthritis, rheumatoid arthritis, muscle pain, and dysmenorrhea.
Uses & Indications
Dosage
Adults
5 mg once or twice daily, or as directed by physician. Maximum recommended daily dose is 10 mg.
Elderly
Initiate with the lowest effective dose (e.g., 5 mg once daily) and monitor closely due to increased risk of adverse effects.
Renal_impairment
Dosage adjustment may be required. Use with caution in patients with moderate to severe renal impairment. Not recommended in severe renal failure.
How to Take
Take Sinacet 5 mg Tablet orally with food or milk to minimize gastrointestinal discomfort. Do not crush or chew the tablet; swallow it whole.
Mechanism of Action
Sinacet works by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever, so by reducing their production, Sinacet alleviates these symptoms.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Mainly excreted in the urine as metabolites, with a small portion in feces.
Half life
Approximately 6-8 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract after oral administration.
Metabolism
Extensively metabolized in the liver, primarily via CYP2C9.
Side Effects
Contraindications
- Hypersensitivity to Sinacet or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
ACE inhibitors and diuretics
Reduced antihypertensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive treatment. Gastric lavage or activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy Category C (D in third trimester). Avoid use in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution during lactation; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Sinacet or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
ACE inhibitors and diuretics
Reduced antihypertensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive treatment. Gastric lavage or activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy Category C (D in third trimester). Avoid use in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution during lactation; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patented
Clinical Trials
Clinical trials for Sinacet 5 mg demonstrated significant efficacy in reducing pain and inflammation associated with musculoskeletal conditions, with a favorable safety profile compared to placebo. Phase III trials confirmed its therapeutic benefits.
Lab Monitoring
- Monitor renal function (creatinine, BUN)
- Monitor liver function (ALT, AST)
- Monitor complete blood count (CBC) during long-term therapy
Doctor Notes
- Assess cardiovascular and gastrointestinal risk factors before prescribing.
- Use the lowest effective dose for the shortest possible duration.
- Monitor renal function, liver function, and blood pressure periodically during long-term therapy.
Patient Guidelines
- Take with food to reduce stomach upset.
- Do not exceed the prescribed dose.
- Inform your doctor about all other medications you are taking.
- Report any signs of unusual bleeding or black stools immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Sinacet may cause dizziness or drowsiness. Patients should be cautioned about engaging in activities requiring mental alertness such as driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption while taking Sinacet.
- Stay well-hydrated.
- Avoid smoking.
- Limit prolonged exposure to sunlight as some NSAIDs can cause photosensitivity.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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