Sinaferon
Generic Name
Interferon Alfa-2b
Manufacturer
SinaPharm Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sinaferon 200 mg capsule | ৳ 0.57 | ৳ 5.70 |
Description
Overview of the medicine
Sinaferon 200 mg Capsule is a hypothetical oral formulation of Interferon Alfa-2b. It is an antiviral, antiproliferative, and immunomodulatory agent used in the treatment of various viral infections and certain types of cancer. While Interferon Alfa-2b is typically administered by injection, this represents a conceptual oral capsule for patient convenience.
Uses & Indications
Dosage
Adults
Dosage varies greatly based on indication, severity, and patient response. Typically administered once daily or thrice weekly, with a much higher mg dose compared to injected IU doses for therapeutic effect.
Elderly
Similar to adults, with cautious monitoring due to potential age-related organ impairment.
Renal_impairment
Dose adjustment may be required in patients with severe renal impairment; careful monitoring is essential.
How to Take
Administer orally with or without food, as directed by a healthcare professional. Swallow the capsule whole; do not chew, crush, or open it.
Mechanism of Action
Interferon Alfa-2b binds to specific receptors on the cell surface, inducing the expression of various genes that inhibit viral replication, suppress cell proliferation, and enhance immune responses.
Pharmacokinetics
Onset
Several hours to days for full immunomodulatory effect.
Excretion
Metabolites are excreted renally.
Half life
Dependent on formulation, potentially longer than injected form; approximately 8-12 hours for active fragments/effects.
Absorption
Variable oral absorption, potentially enhanced by specific formulation technology.
Metabolism
Primarily catabolized by proteases in the liver and kidney.
Side Effects
Contraindications
- Hypersensitivity to Interferon Alfa-2b or any component of the formulation
- Severe autoimmune disease
- Decompensated liver disease
- Severe cardiac disease (e.g., unstable angina, decompensated heart failure)
- History of severe psychiatric disorder, especially depression with suicidal ideation
Drug Interactions
Methadone
Potential for increased serum concentrations of methadone.
Zidovudine
Increased risk of myelosuppression when co-administered with zidovudine.
Theophylline
May increase serum concentrations of theophylline, requiring dose adjustment.
Myelosuppressive agents
Concomitant use with other myelosuppressive agents may increase the risk of bone marrow suppression.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Management is primarily supportive and symptomatic. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C/D. Use only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing mother, or discontinuation of breastfeeding should be considered.
Side Effects
Contraindications
- Hypersensitivity to Interferon Alfa-2b or any component of the formulation
- Severe autoimmune disease
- Decompensated liver disease
- Severe cardiac disease (e.g., unstable angina, decompensated heart failure)
- History of severe psychiatric disorder, especially depression with suicidal ideation
Drug Interactions
Methadone
Potential for increased serum concentrations of methadone.
Zidovudine
Increased risk of myelosuppression when co-administered with zidovudine.
Theophylline
May increase serum concentrations of theophylline, requiring dose adjustment.
Myelosuppressive agents
Concomitant use with other myelosuppressive agents may increase the risk of bone marrow suppression.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Management is primarily supportive and symptomatic. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C/D. Use only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing mother, or discontinuation of breastfeeding should be considered.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Global (Hypothetical)
Approval Status
Approved (Hypothetical formulation)
Patent Status
Proprietary formulation
Clinical Trials
Clinical trials for oral interferon formulations are ongoing to assess efficacy, safety, and pharmacokinetics compared to injectable forms.
Lab Monitoring
- Complete Blood Count (CBC) with differential
- Liver Function Tests (ALT, AST)
- Thyroid Function Tests (TSH)
- Renal Function Tests (creatinine)
- Electrolytes
- Periodic psychiatric evaluation
Doctor Notes
- Monitor patients closely for neuropsychiatric side effects, especially depression and suicidal ideation, and intervene promptly if observed.
- Educate patients thoroughly about common flu-like symptoms and strategies for managing them.
- Emphasize strict adherence to the dosing regimen and regular follow-up for optimal outcomes and safety monitoring.
Patient Guidelines
- Adhere strictly to the prescribed dosing schedule.
- Report any severe side effects, especially mood changes or flu-like symptoms, to your doctor immediately.
- Avoid alcohol consumption during treatment.
- Attend all scheduled follow-up appointments and laboratory tests.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause fatigue, dizziness, or confusion. Patients should exercise caution when driving or operating hazardous machinery until they know how the drug affects them.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Ensure adequate hydration.
- Practice stress management techniques.
- Avoid strenuous activities if experiencing significant fatigue.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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