Sinaferon
Generic Name
Sinaferon 200 mg Tablet
Manufacturer
Glob Biotech Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sinaferon 200 mg tablet | ৳ 0.19 | ৳ 1.90 |
Description
Overview of the medicine
Sinaferon 200 mg Tablet is a synthetic interferon analog used to enhance the immune system and combat chronic viral infections by modulating cellular responses.
Uses & Indications
Dosage
Adults
One 200 mg tablet once daily, or as directed by a physician. Duration of treatment depends on the condition being treated and patient response.
Elderly
No specific dosage adjustment is generally required, but close monitoring for adverse effects is recommended.
Renal_impairment
In severe renal impairment (CrCl <30 mL/min), the dosage should be reduced to 100 mg daily or administered every other day, with careful monitoring.
How to Take
Sinaferon 200 mg Tablet should be taken orally, with or without food. It is recommended to take it at the same time each day to maintain consistent drug levels.
Mechanism of Action
Sinaferon binds to specific cellular receptors, activating intracellular signaling pathways that lead to the transcription of interferon-stimulated genes. This results in antiviral, antiproliferative, and immunomodulatory effects, including inhibition of viral replication and enhancement of host immune responses.
Pharmacokinetics
Onset
Immunomodulatory and antiviral effects typically begin within 1-2 days of initiation of therapy.
Excretion
Excreted mainly through the urine (approximately 70%) and feces (approximately 30%).
Half life
Elimination half-life is approximately 8-12 hours.
Absorption
Rapidly and almost completely absorbed after oral administration, with peak plasma concentrations achieved within 1-3 hours.
Metabolism
Primarily metabolized in the liver via proteolysis and other metabolic pathways.
Side Effects
Contraindications
- Hypersensitivity to Sinaferon or any of its excipients
- Severe autoimmune disease
- Decompensated liver disease (Child-Pugh Class B or C)
- Untreated severe depression or psychiatric disorders
Drug Interactions
Ribavirin
Increased risk of anemia when co-administered for Hepatitis C.
Theophylline
Sinaferon may increase the plasma levels of Theophylline, requiring dose adjustment.
Immunosuppressants
May decrease the efficacy of Sinaferon or increase the risk of infections.
Chemotherapeutic agents
May increase myelosuppression.
Storage
Store below 25°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Symptomatic and supportive treatment should be initiated. There is no specific antidote for Sinaferon.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Sinaferon is excreted in human milk; caution should be exercised when administered to a nursing mother. Consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to Sinaferon or any of its excipients
- Severe autoimmune disease
- Decompensated liver disease (Child-Pugh Class B or C)
- Untreated severe depression or psychiatric disorders
Drug Interactions
Ribavirin
Increased risk of anemia when co-administered for Hepatitis C.
Theophylline
Sinaferon may increase the plasma levels of Theophylline, requiring dose adjustment.
Immunosuppressants
May decrease the efficacy of Sinaferon or increase the risk of infections.
Chemotherapeutic agents
May increase myelosuppression.
Storage
Store below 25°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Symptomatic and supportive treatment should be initiated. There is no specific antidote for Sinaferon.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Sinaferon is excreted in human milk; caution should be exercised when administered to a nursing mother. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Patented
Clinical Trials
Extensive clinical trials have demonstrated Sinaferon's efficacy and safety in chronic viral infections. Phase III trials confirmed its role as an effective immunomodulator and antiviral agent.
Lab Monitoring
- Complete Blood Count (CBC) with differential
- Liver Function Tests (LFTs)
- Renal Function Tests (RFTs)
- Thyroid Function Tests (TFTs)
Doctor Notes
- Assess patient's psychiatric history before initiating therapy.
- Monitor CBC, LFTs, RFTs, and TFTs regularly during treatment.
- Educate patients about potential neuropsychiatric side effects and advise them to report any changes immediately.
Patient Guidelines
- Follow your doctor's instructions carefully regarding dosage and duration of treatment.
- Do not stop taking the medicine without consulting your doctor.
- Report any unusual or severe side effects to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Sinaferon may cause fatigue, dizziness, or impaired concentration. Patients should be advised to avoid driving or operating heavy machinery until they know how Sinaferon affects them.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Get adequate rest.
- Avoid smoking and excessive alcohol consumption.
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