Sinafort-B
Generic Name
Vitamin B Complex
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sinafort b 5 mg capsule | ৳ 1.00 | ৳ 10.00 |
Description
Overview of the medicine
Sinafort-B 5 mg Capsule is a vitamin B complex preparation indicated for the prevention and treatment of vitamin B deficiencies and associated neurological symptoms. It helps in maintaining overall health and well-being.
Uses & Indications
Dosage
Adults
1-2 capsules daily or as directed by a physician. In severe deficiency, higher doses may be prescribed initially.
Elderly
Same as adult dose, but caution may be advised in individuals with significant renal impairment.
Renal_impairment
Dose adjustment may be necessary in severe renal impairment, especially for certain B vitamins. Consult a physician.
How to Take
Oral administration. Can be taken with or without food. For best absorption and to minimize gastrointestinal upset, it is often recommended to take with a meal.
Mechanism of Action
B vitamins act as coenzymes in various crucial metabolic pathways. They are essential for carbohydrate, fat, and protein metabolism, cellular respiration, energy production, and maintaining healthy nervous system function. Each B vitamin plays a specific role in these processes.
Pharmacokinetics
Onset
Variable; effects on metabolic processes are gradual and depend on the severity of deficiency. Therapeutic effects may be noticed over days to weeks.
Excretion
Excreted primarily in urine as metabolites and unabsorbed forms. Riboflavin (B2) can cause urine to turn bright yellow.
Half life
Highly variable for individual B vitamins. Most are water-soluble and have relatively short half-lives, being rapidly excreted if not utilized.
Absorption
Readily absorbed from the gastrointestinal tract, primarily in the small intestine. Absorption can be affected by certain conditions or drugs.
Metabolism
Primarily metabolized in the liver to their active coenzyme forms. Excess amounts, particularly of certain B vitamins, are not stored significantly.
Side Effects
Contraindications
- Hypersensitivity to any active ingredient or excipient in the formulation.
- Leber's hereditary optic atrophy (due to Vitamin B12, as it may exacerbate the condition).
Drug Interactions
Alcohol
Chronic alcohol consumption impairs the absorption and utilization of several B vitamins, leading to deficiency.
Levodopa
Pyridoxine (Vitamin B6) can reduce the efficacy of Levodopa, an anti-Parkinsonian drug. This interaction is less significant with newer Levodopa/Carbidopa combinations.
Oral contraceptives
Long-term use of oral contraceptives may lead to reduced levels of certain B vitamins, particularly B6 and Folic Acid.
Certain antibiotics (e.g., Isoniazid, Cycloserine)
May interfere with the metabolism or increase the excretion of Vitamin B6, potentially leading to deficiency.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
B vitamins are water-soluble, and excess amounts are typically excreted in the urine. Serious overdose is rare. However, very high, prolonged doses of Vitamin B6 (Pyridoxine) can lead to peripheral sensory neuropathy, characterized by numbness and tingling in the extremities. Treatment involves discontinuing the supplement and supportive care.
Pregnancy & Lactation
Sinafort-B is generally considered safe for use during pregnancy and lactation when taken at recommended doses, as B vitamins are essential for fetal development and maternal health. However, always consult a healthcare professional before taking any medication during these periods.
Side Effects
Contraindications
- Hypersensitivity to any active ingredient or excipient in the formulation.
- Leber's hereditary optic atrophy (due to Vitamin B12, as it may exacerbate the condition).
Drug Interactions
Alcohol
Chronic alcohol consumption impairs the absorption and utilization of several B vitamins, leading to deficiency.
Levodopa
Pyridoxine (Vitamin B6) can reduce the efficacy of Levodopa, an anti-Parkinsonian drug. This interaction is less significant with newer Levodopa/Carbidopa combinations.
Oral contraceptives
Long-term use of oral contraceptives may lead to reduced levels of certain B vitamins, particularly B6 and Folic Acid.
Certain antibiotics (e.g., Isoniazid, Cycloserine)
May interfere with the metabolism or increase the excretion of Vitamin B6, potentially leading to deficiency.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
B vitamins are water-soluble, and excess amounts are typically excreted in the urine. Serious overdose is rare. However, very high, prolonged doses of Vitamin B6 (Pyridoxine) can lead to peripheral sensory neuropathy, characterized by numbness and tingling in the extremities. Treatment involves discontinuing the supplement and supportive care.
Pregnancy & Lactation
Sinafort-B is generally considered safe for use during pregnancy and lactation when taken at recommended doses, as B vitamins are essential for fetal development and maternal health. However, always consult a healthcare professional before taking any medication during these periods.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture, depending on the specific formulation and storage conditions.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Generic available, no longer patented
WHO Essential Medicine
YesClinical Trials
Extensive clinical evidence and decades of widespread use support the efficacy and safety of B vitamins in preventing and treating deficiencies. Specific clinical trials for this particular brand might exist but generally, B-complex formulations rely on the established science of individual vitamins.
Lab Monitoring
- Serum B vitamin levels (if clinical deficiency is suspected or to monitor treatment effectiveness)
- Routine blood tests (e.g., complete blood count) to assess overall health and rule out other causes of symptoms.
Doctor Notes
- Emphasize the importance of a balanced diet alongside supplementation.
- Advise patients on potential urine discoloration and assure them it is harmless.
- Consider underlying causes for persistent B vitamin deficiency.
- Counsel patients on potential interaction with Levodopa, especially in older formulations.
Patient Guidelines
- Take the capsule whole with water; do not crush or chew.
- Follow the prescribed dosage and duration of treatment.
- Inform your doctor about all other medications and supplements you are taking.
- If you experience any unusual or severe side effects, consult your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Sinafort-B is not known to affect the ability to drive or operate machinery. However, if you experience any dizziness or adverse effects, avoid such activities.
Lifestyle Advice
- Maintain a balanced and nutritious diet rich in whole grains, lean meats, fish, dairy products, fruits, and vegetables to ensure adequate B vitamin intake.
- Limit or avoid excessive alcohol consumption, as it can deplete B vitamin levels.
- Regular physical activity and stress management techniques can also contribute to overall well-being.
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