Sinecod SR
Generic Name
Butamirate Citrate
Manufacturer
Novartis (original), often local licensees
Country
Switzerland (originator), many countries produce locally
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sinecod sr 50 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Sinecod SR is used for the symptomatic treatment of non-productive (dry) cough of various etiologies. It contains Butamirate Citrate as an active ingredient, which acts centrally to suppress the cough reflex.
Uses & Indications
Dosage
Adults
One Sinecod SR 50 mg tablet twice daily (morning and evening).
Elderly
Same as adult dosage, but caution with other comorbidities.
Renal_impairment
No specific dose adjustment required, but use with caution in severe renal impairment.
How to Take
Swallow the tablet whole with water. Do not chew or crush. Can be taken with or without food.
Mechanism of Action
Butamirate Citrate is a centrally acting non-opioid antitussive agent. It depresses the cough center in the brain, thereby reducing the frequency and intensity of coughing. It is not chemically related to opium alkaloids.
Pharmacokinetics
Onset
Antitussive effect usually within 30-60 minutes.
Excretion
Mainly excreted by the kidneys, primarily as metabolites.
Half life
Approximately 4-6 hours for Butamirate and 14-16 hours for its active metabolites.
Absorption
Well absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 1-1.5 hours for immediate release, and about 9 hours for sustained release formulations.
Metabolism
Undergoes hydrolysis to two active metabolites (2-phenylbutyric acid and diethylaminoethoxyethanol), which are extensively metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Butamirate Citrate or any excipients
- First trimester of pregnancy
- Children under 6 years for SR formulation
Drug Interactions
CNS Depressants
Potentially enhanced sedative effects when used concomitantly with other CNS depressants (e.g., alcohol, hypnotics, sedatives).
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, diarrhea, and dizziness. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal if appropriate.
Pregnancy & Lactation
Not recommended during the first trimester of pregnancy. Use with caution during the second and third trimesters only if clearly needed and after consulting a doctor. Avoid during lactation as it is unknown if it passes into breast milk.
Side Effects
Contraindications
- Hypersensitivity to Butamirate Citrate or any excipients
- First trimester of pregnancy
- Children under 6 years for SR formulation
Drug Interactions
CNS Depressants
Potentially enhanced sedative effects when used concomitantly with other CNS depressants (e.g., alcohol, hypnotics, sedatives).
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, diarrhea, and dizziness. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal if appropriate.
Pregnancy & Lactation
Not recommended during the first trimester of pregnancy. Use with caution during the second and third trimesters only if clearly needed and after consulting a doctor. Avoid during lactation as it is unknown if it passes into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies
Approval Status
Approved in various countries
Patent Status
Off-patent
Clinical Trials
Butamirate Citrate has been studied in clinical trials for its efficacy and safety in relieving cough.
Lab Monitoring
- No specific lab monitoring required.
Doctor Notes
- Differentiate between productive and non-productive cough before prescribing.
- Advise patients on symptomatic relief and underlying cause investigation if cough persists.
Patient Guidelines
- Do not use for more than 7 days without consulting a doctor.
- If cough persists or worsens, or if accompanied by fever, rash, or persistent headache, consult a doctor.
- Keep out of reach of children.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness in some individuals. Patients should be cautioned about operating machinery or driving if affected.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Avoid irritants like smoke and dust.
- Use a humidifier to keep the air moist.
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