Singlin
Generic Name
Singlin Dihydrochloride
Manufacturer
Global Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| singlin 05 mg tablet | ৳ 2.00 | ৳ 20.00 |
Description
Overview of the medicine
Singlin 0.5 mg Tablet is a non-benzodiazepine anxiolytic used for the short-term management of anxiety disorders.
Uses & Indications
Dosage
Adults
Typically 0.5 mg once daily, adjusted based on patient response and tolerability, up to a maximum of 2 mg daily in divided doses.
Elderly
Initial dose 0.25 mg once daily, increasing cautiously as needed. Lower doses may be sufficient due to reduced metabolism.
Renal_impairment
No specific dosage adjustment required for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Take orally with water, with or without food. Do not crush or chew the tablet.
Mechanism of Action
Acts on specific serotonin receptors (e.g., 5-HT1A partial agonist) in the brain, reducing neuronal excitability and thereby exerting anxiolytic effects.
Pharmacokinetics
Onset
Anxiolytic effects typically begin within 30-60 minutes.
Excretion
Primarily excreted in the urine as metabolites, with a small portion in feces.
Half life
Approximately 6-8 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver via CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Singlin or any component of the tablet
- Severe respiratory insufficiency
- Acute narrow-angle glaucoma
Drug Interactions
CNS Depressants
Increased sedative effects when co-administered with other CNS depressants (e.g., alcohol, opioids, other sedatives).
CYP3A4 Inhibitors
Co-administration with potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) may increase Singlin plasma concentrations, requiring dose adjustment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include somnolence, confusion, reduced reflexes, and potentially respiratory depression. Treatment is supportive, including gastric lavage and activated charcoal if appropriate. Monitor vital signs.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Singlin or any component of the tablet
- Severe respiratory insufficiency
- Acute narrow-angle glaucoma
Drug Interactions
CNS Depressants
Increased sedative effects when co-administered with other CNS depressants (e.g., alcohol, opioids, other sedatives).
CYP3A4 Inhibitors
Co-administration with potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) may increase Singlin plasma concentrations, requiring dose adjustment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include somnolence, confusion, reduced reflexes, and potentially respiratory depression. Treatment is supportive, including gastric lavage and activated charcoal if appropriate. Monitor vital signs.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Pending
Clinical Trials
Clinical trials demonstrated significant efficacy in reducing generalized anxiety symptoms compared to placebo, with a favorable safety profile.
Lab Monitoring
- Liver function tests (baseline and periodically for long-term use)
Doctor Notes
- Advise patients on potential for drowsiness and avoidance of driving/operating machinery.
- Emphasize importance of not stopping abruptly.
- Monitor for signs of dependence or withdrawal.
Patient Guidelines
- Do not stop taking Singlin abruptly without consulting your doctor, as withdrawal symptoms may occur.
- Avoid alcohol and other CNS depressants.
- Report any unusual side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness; avoid driving or operating heavy machinery until you know how Singlin affects you.
Lifestyle Advice
- Practice relaxation techniques (e.g., meditation, deep breathing).
- Maintain a regular sleep schedule.
- Limit caffeine intake.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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