Singlin
Generic Name
Singlin-1-mg-tablet
Manufacturer
MediCorp Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| singlin 1 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Singlin 1 mg Tablet contains Singlin, a Dipeptidyl Peptidase-4 (DPP-4) inhibitor, indicated for the treatment of type 2 diabetes mellitus in adults, as an adjunct to diet and exercise.
Uses & Indications
Dosage
Adults
The recommended dose of Singlin is 1 mg once daily, taken orally with or without food.
Elderly
No dose adjustment is required based on age alone.
Renal_impairment
No dose adjustment is required for patients with any degree of renal impairment.
How to Take
Take Singlin 1 mg Tablet orally once daily, with or without food. Swallow the tablet whole with water. Do not crush, chew, or break the tablet.
Mechanism of Action
Singlin selectively inhibits the enzyme DPP-4, which is responsible for the inactivation of incretin hormones (GLP-1 and GIP). By preventing their degradation, Singlin increases the levels of active incretin hormones, leading to enhanced glucose-dependent insulin secretion and suppressed glucagon secretion, thus improving glycemic control.
Pharmacokinetics
Onset
Glycemic control improvement generally seen within the first few weeks of therapy.
Excretion
Primarily excreted via bile and feces; minor renal excretion.
Half life
Approximately 12-15 hours for effective DPP-4 inhibition.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached within 1 to 2 hours.
Metabolism
Minimally metabolized; primary elimination via unchanged excretion.
Side Effects
Contraindications
- Known hypersensitivity to Singlin or any component of the tablet.
- Patients with type 1 diabetes mellitus.
- Patients with diabetic ketoacidosis.
Drug Interactions
Digoxin
Monitor digoxin levels if co-administered, as Singlin may slightly increase digoxin exposure.
Rifampicin
May reduce the efficacy of Singlin; consider alternative antidiabetic agents.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, discontinue Singlin and initiate appropriate symptomatic and supportive measures. Singlin is not effectively removed by hemodialysis or peritoneal dialysis.
Pregnancy & Lactation
Limited human data on use during pregnancy and lactation. Use only if the potential benefit justifies the potential risk to the fetus or infant. Consult your healthcare provider.
Side Effects
Contraindications
- Known hypersensitivity to Singlin or any component of the tablet.
- Patients with type 1 diabetes mellitus.
- Patients with diabetic ketoacidosis.
Drug Interactions
Digoxin
Monitor digoxin levels if co-administered, as Singlin may slightly increase digoxin exposure.
Rifampicin
May reduce the efficacy of Singlin; consider alternative antidiabetic agents.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, discontinue Singlin and initiate appropriate symptomatic and supportive measures. Singlin is not effectively removed by hemodialysis or peritoneal dialysis.
Pregnancy & Lactation
Limited human data on use during pregnancy and lactation. Use only if the potential benefit justifies the potential risk to the fetus or infant. Consult your healthcare provider.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by national regulatory bodies
Patent Status
Under patent protection
Clinical Trials
Clinical trials have demonstrated Singlin's efficacy and safety in improving glycemic control in adults with type 2 diabetes. Long-term studies are ongoing to evaluate cardiovascular outcomes.
Lab Monitoring
- Periodically monitor HbA1c to assess glycemic control.
- Routine blood glucose monitoring as advised by the physician.
Doctor Notes
- Emphasize the importance of adherence to diet and exercise.
- Assess for signs of pancreatitis (persistent severe abdominal pain).
- Monitor for symptoms of hypoglycemia, especially in combination therapy.
Patient Guidelines
- Take the tablet at the same time each day to maintain consistent blood levels.
- Follow your doctor's advice on diet and exercise.
- Report any new or worsening symptoms to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at once.
Driving Precautions
Singlin is not known to affect the ability to drive or operate machinery. However, if taken with other medications that can cause hypoglycemia (e.g., sulfonylureas, insulin), caution is advised, as hypoglycemia can impair concentration.
Lifestyle Advice
- Maintain a healthy weight.
- Engage in regular physical activity.
- Follow a balanced diet low in saturated fats and refined sugars.
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Global Brand Names
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