Sitagil
Generic Name
Sitagliptin
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sitagil 100 mg tablet | ৳ 28.00 | ৳ 280.00 |
Description
Overview of the medicine
Sitagliptin 100 mg tablet is an oral antidiabetic medication used to improve glycemic control in adults with type 2 diabetes mellitus.
Uses & Indications
Dosage
Adults
The recommended dose is 100 mg once daily, taken orally with or without food.
Elderly
No dosage adjustment is required based on age alone. However, renal function should be assessed.
Renal_impairment
For mild renal impairment (CrCl ≥ 50 mL/min): 100 mg once daily. For moderate renal impairment (CrCl ≥ 30 to < 50 mL/min): 50 mg once daily. For severe renal impairment (CrCl < 30 mL/min) or end-stage renal disease requiring dialysis: 25 mg once daily.
How to Take
Take orally once daily, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that works by increasing the levels of active incretin hormones (glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)). These hormones are released by the intestine throughout the day and their levels increase in response to a meal. Incretins are part of an endogenous system involved in the physiological regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase insulin synthesis and release from pancreatic beta cells. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduced hepatic glucose production. DPP-4 is an enzyme that rapidly degrades incretin hormones. Sitagliptin prevents this degradation, leading to higher levels of active incretins, thereby improving glycemic control.
Pharmacokinetics
Onset
Within hours (for glucose-lowering effect).
Excretion
Primarily renal excretion (approximately 79% unchanged in urine), with minor fecal excretion.
Half life
Approximately 12.4 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations (Tmax) reached in 1 to 4 hours. Absolute bioavailability is approximately 87%.
Metabolism
Approximately 79% of Sitagliptin is excreted unchanged in the urine. Limited metabolism, primarily by CYP3A4 and to a lesser extent by CYP2C8.
Side Effects
Contraindications
- Hypersensitivity to sitagliptin or any component of the formulation.
- Patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.
Drug Interactions
Digoxin
No clinically meaningful interaction was observed, but close monitoring is advised for patients taking digoxin with sitagliptin.
Cyclosporine
Concurrent use of cyclosporine may increase sitagliptin plasma levels, but this is not considered clinically significant.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, contact a poison control center or emergency room. Treatment is symptomatic and supportive. Sitagliptin is modestly dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no teratogenic effects, but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. It is unknown if sitagliptin is excreted in human milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to sitagliptin or any component of the formulation.
- Patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.
Drug Interactions
Digoxin
No clinically meaningful interaction was observed, but close monitoring is advised for patients taking digoxin with sitagliptin.
Cyclosporine
Concurrent use of cyclosporine may increase sitagliptin plasma levels, but this is not considered clinically significant.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, contact a poison control center or emergency room. Treatment is symptomatic and supportive. Sitagliptin is modestly dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no teratogenic effects, but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. It is unknown if sitagliptin is excreted in human milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals
Approval Status
Approved by FDA and local regulatory authorities (e.g., DGDA)
Patent Status
Patent expired for generic versions
Clinical Trials
Sitagliptin has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in improving glycemic control in type 2 diabetes patients, both as monotherapy and in combination with other antidiabetic agents.
Lab Monitoring
- Blood glucose levels
- HbA1c levels
- Renal function (e.g., serum creatinine, eGFR) periodically
Doctor Notes
- Advise patients on lifestyle modifications (diet and exercise) alongside sitagliptin therapy.
- Monitor renal function before and periodically during treatment.
- Be aware of the risk of hypoglycemia when co-administered with sulfonylureas or insulin and consider reducing their dose.
- Educate patients on symptoms of pancreatitis and hypersensitivity reactions.
Patient Guidelines
- Take this medicine regularly as prescribed by your doctor.
- Do not stop taking it without consulting your doctor, even if you feel well.
- Maintain a healthy diet and regular exercise regimen as advised by your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Sitagliptin generally does not cause hypoglycemia when used alone, so it is unlikely to affect the ability to drive or operate machinery. However, if used in combination with a sulfonylurea or insulin, hypoglycemia may occur, which could impair driving ability. Patients should be aware of the symptoms of hypoglycemia.
Lifestyle Advice
- Adopt a balanced diet low in sugar and saturated fats.
- Engage in regular physical activity.
- Monitor blood sugar levels as instructed by your doctor.
- Avoid smoking and excessive alcohol consumption.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Sitagil Brand
Other medicines available under the same brand name
