Sitagil
Generic Name
Sitagliptin 50 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sitagil 50 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Sitagil 50 mg Tablet contains Sitagliptin, an oral anti-diabetic drug used to improve blood sugar control in adults with type 2 diabetes mellitus. It is used as an adjunct to diet and exercise.
Uses & Indications
Dosage
Adults
The recommended dose is 100 mg once daily, with or without food. For Sitagil 50 mg, it's typically used when titration or lower doses are required.
Elderly
No dosage adjustment is required based on age alone. Adjust dosage for renal impairment.
Renal_impairment
For moderate renal impairment (CrCl ≥30 to <50 mL/min), the dose is 50 mg once daily. For severe renal impairment (CrCl <30 mL/min) or ESRD requiring dialysis, the dose is 25 mg once daily.
How to Take
Take Sitagil 50 mg Tablet orally once daily, with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by inhibiting the enzyme DPP-4, which is responsible for inactivating incretin hormones (GLP-1 and GIP). By preserving active incretin levels, Sitagliptin increases insulin synthesis and release from pancreatic beta cells and decreases glucagon secretion from pancreatic alpha cells, both in a glucose-dependent manner. This leads to improved glycemic control.
Pharmacokinetics
Onset
Within 24 hours (effects on glucose observed)
Excretion
Primarily excreted unchanged in the urine (about 79% of the dose).
Half life
Approximately 12.4 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in 1 to 4 hours.
Metabolism
Limited metabolism, primarily by CYP3A4, with minor contribution from CYP2C8.
Side Effects
Contraindications
- Hypersensitivity to Sitagliptin or any component of the tablet.
- Patients with type 1 diabetes mellitus.
- Patients with diabetic ketoacidosis.
Drug Interactions
Digoxin
Sitagliptin has a minor effect on digoxin plasma concentrations; no dosage adjustment is generally needed for digoxin.
Cyclosporine
No clinically meaningful interaction observed.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, initiate appropriate supportive treatment as dictated by the patient’s clinical status. Hemodialysis removes approximately 13.5% of the dose over a 3- to 4-hour dialysis session.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. It is not known whether Sitagliptin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Sitagliptin or any component of the tablet.
- Patients with type 1 diabetes mellitus.
- Patients with diabetic ketoacidosis.
Drug Interactions
Digoxin
Sitagliptin has a minor effect on digoxin plasma concentrations; no dosage adjustment is generally needed for digoxin.
Cyclosporine
No clinically meaningful interaction observed.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, initiate appropriate supportive treatment as dictated by the patient’s clinical status. Hemodialysis removes approximately 13.5% of the dose over a 3- to 4-hour dialysis session.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. It is not known whether Sitagliptin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from the date of manufacture
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
Clinical Trials
Sitagliptin has been evaluated in numerous clinical trials, including large-scale cardiovascular outcome trials such as TECOS (Trial Evaluating Cardiovascular Outcomes with Sitagliptin) which demonstrated cardiovascular safety.
Lab Monitoring
- Monitor HbA1c periodically to assess glycemic control.
- Monitor renal function (e.g., eGFR) before initiating and periodically during treatment, especially in patients with known renal impairment.
- Monitor liver function tests periodically.
Doctor Notes
- Assess renal function prior to initiating Sitagliptin and periodically thereafter.
- Monitor for symptoms of pancreatitis (e.g., persistent severe abdominal pain). Discontinue if pancreatitis is suspected.
- Advise patients on the signs and symptoms of hypersensitivity reactions and instruct them to discontinue the drug and seek immediate medical attention if these occur.
Patient Guidelines
- Take your medicine regularly as prescribed by your doctor.
- Maintain a healthy diet and regular exercise regimen.
- Report any unusual symptoms or side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Sitagliptin alone is not expected to affect the ability to drive or use machines. However, if Sitagil is used in combination with a sulfonylurea or insulin, hypoglycemia can occur, which might impair the ability to drive or operate machinery. Patients should be advised about the risk of hypoglycemia and how to manage it.
Lifestyle Advice
- Adopt a balanced diet low in sugar and refined carbohydrates.
- Engage in at least 30 minutes of moderate-intensity exercise most days of the week.
- Maintain a healthy weight.
- Avoid smoking and excessive alcohol consumption.
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