Slimi
Generic Name
Orlistat
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| slimi 60 mg capsule | ৳ 30.00 | ৳ 210.00 |
Description
Overview of the medicine
Slimi (Orlistat) is a lipase inhibitor medicine used for weight management in obese or overweight individuals. It works by preventing the absorption of about one-third of the fat from the food eaten.
Uses & Indications
Dosage
Adults
120 mg capsule orally three times a day with each main meal containing fat
Elderly
No specific dose adjustment required
Renal_impairment
No specific dose adjustment required, but caution is advised in severe renal impairment
How to Take
Take orally with water during or up to 1 hour after each main meal. If a meal is missed or contains no fat, the dose can be skipped.
Mechanism of Action
Orlistat inhibits gastrointestinal lipases (enzymes that break down fat). This prevents the hydrolysis of dietary triglycerides into absorbable free fatty acids and monoglycerides, thereby reducing the absorption of dietary fat.
Pharmacokinetics
Onset
Within 24-48 hours
Excretion
Primarily via feces (approximately 97% of the dose is excreted in the feces, with 83% as unchanged drug)
Half life
Approximately 1-2 hours (plasma elimination half-life is longer, ~14 hours, but systemic absorption is minimal)
Absorption
Minimal systemic absorption (less than 1%)
Metabolism
Primarily in the gastrointestinal tract; minimal systemic metabolism
Side Effects
Contraindications
- Chronic malabsorption syndrome
- Cholestasis
- Pregnancy and breastfeeding
- Hypersensitivity to orlistat or any component
Drug Interactions
Warfarin
Increased INR (International Normalized Ratio) due to reduced vitamin K absorption.
Cyclosporine
Reduced plasma concentrations of cyclosporine. Administer cyclosporine at least 3 hours after orlistat.
Levothyroxine
Reduced absorption of levothyroxine. Administer levothyroxine at least 4 hours apart from orlistat.
Fat-soluble vitamins (A, D, E, K)
Reduced absorption of fat-soluble vitamins. Supplementation may be needed.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Cases of overdose have been reported with no significant adverse events. Symptoms generally similar to known side effects. Supportive care recommended.
Pregnancy & Lactation
Contraindicated during pregnancy and breastfeeding. Limited data available, potential risks outweigh benefits.
Side Effects
Contraindications
- Chronic malabsorption syndrome
- Cholestasis
- Pregnancy and breastfeeding
- Hypersensitivity to orlistat or any component
Drug Interactions
Warfarin
Increased INR (International Normalized Ratio) due to reduced vitamin K absorption.
Cyclosporine
Reduced plasma concentrations of cyclosporine. Administer cyclosporine at least 3 hours after orlistat.
Levothyroxine
Reduced absorption of levothyroxine. Administer levothyroxine at least 4 hours apart from orlistat.
Fat-soluble vitamins (A, D, E, K)
Reduced absorption of fat-soluble vitamins. Supplementation may be needed.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Cases of overdose have been reported with no significant adverse events. Symptoms generally similar to known side effects. Supportive care recommended.
Pregnancy & Lactation
Contraindicated during pregnancy and breastfeeding. Limited data available, potential risks outweigh benefits.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available, patent expired
Clinical Trials
Numerous clinical trials have demonstrated orlistat's efficacy in weight loss and maintenance, as well as improvement in obesity-related comorbidities.
Lab Monitoring
- Liver function tests (baseline and periodically, especially if symptoms of liver injury develop)
- INR in patients on warfarin
- Cyclosporine levels if co-administered
Doctor Notes
- Emphasize the importance of a low-fat diet for managing side effects.
- Counsel patients on the need for fat-soluble vitamin supplementation.
- Monitor for signs of liver dysfunction.
Patient Guidelines
- Follow a reduced-calorie, low-fat diet.
- Take a multivitamin supplement containing fat-soluble vitamins daily, separated from orlistat dose by at least 2 hours.
- Be aware of potential gastrointestinal side effects, especially with high-fat meals.
- Report any signs of liver problems (e.g., yellow skin/eyes, dark urine).
Missed Dose Advice
If a dose is missed by more than 1 hour after a main meal, skip the missed dose and continue with the next scheduled dose. Do not take a double dose.
Driving Precautions
Orlistat is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Combine with a balanced diet and regular exercise for optimal weight loss results.
- Maintain adequate hydration.
- Limit intake of high-fat foods to reduce gastrointestinal side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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