Solbion
Generic Name
Vitamin B Complex (Thiamine Mononitrate, Pyridoxine Hydrochloride 100 mg, Cyanocobalamin)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| solbion 100 mg tablet | ৳ 10.00 | N/A |
Description
Overview of the medicine
Solbion-100 mg tablet is a vitamin B complex supplement containing high doses of Thiamine (B1), Pyridoxine (B6), and Cyanocobalamin (B12). It is used to prevent and treat deficiencies of these vitamins, especially in conditions affecting nerve health.
Uses & Indications
Dosage
Adults
Typically 1-3 tablets daily, or as directed by a physician. For severe deficiency, higher doses may be prescribed initially.
Elderly
Same as adult dosage, no specific dose adjustment required unless underlying renal impairment. Consult a physician if concerns arise.
Renal_impairment
No specific dose adjustment for mild to moderate renal impairment. For severe renal impairment, consult a physician due to potential accumulation of pyridoxine metabolites.
How to Take
Oral administration. Tablets can be taken with or without food. Swallow the tablet whole with water, do not chew or crush.
Mechanism of Action
B vitamins act as coenzymes in various metabolic processes. Thiamine is essential for carbohydrate metabolism and nerve function. Pyridoxine is involved in amino acid metabolism, neurotransmitter synthesis, and red blood cell formation. Cyanocobalamin is crucial for DNA synthesis, red blood cell formation, and neurological function.
Pharmacokinetics
Onset
Effects are generally seen over days to weeks with regular supplementation, as underlying deficiencies are corrected.
Excretion
Excreted primarily via the kidneys in urine, largely as metabolites or unabsorbed forms. Excess is rapidly eliminated.
Half life
Variable for individual B vitamins, generally short (hours) for water-soluble vitamins, requiring regular intake. Excess amounts are readily excreted.
Absorption
Readily absorbed from the gastrointestinal tract, primarily in the small intestine, but absorption can be limited by transport mechanisms at very high doses. Absorption of B12 requires intrinsic factor.
Metabolism
Metabolized to their active coenzyme forms in the liver and other tissues, where they participate in various metabolic pathways.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation (Thiamine, Pyridoxine, Cyanocobalamin, or excipients)
- Leber's disease (due to potential for optic nerve damage with B12 in predisposed individuals)
Drug Interactions
Levodopa
Pyridoxine (Vitamin B6) may reduce the efficacy of levodopa (used in Parkinson's disease), although this interaction is less common with levodopa/carbidopa combinations.
Certain antibiotics (e.g., Chloramphenicol)
May interfere with Cyanocobalamin (Vitamin B12) absorption or utilization.
Isoniazid, Oral Contraceptives, Cycloserine, Hydralazine, Penicillamine
These medications may increase the requirement for Pyridoxine, potentially leading to B6 deficiency.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of sight and reach of children.
Overdose
Since B vitamins are water-soluble, excess amounts are generally excreted in urine. However, very high doses of Pyridoxine (B6) over a prolonged period (e.g., >200 mg/day for months or years) can lead to peripheral neuropathy. Management for overdose is symptomatic and supportive; discontinue the drug and seek medical attention.
Pregnancy & Lactation
Generally considered safe and often recommended as supplements during pregnancy and lactation to meet increased nutritional needs. Folic acid (another B vitamin) is crucial for preventing neural tube defects. Always consult a doctor before taking any medication or supplement during these periods.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation (Thiamine, Pyridoxine, Cyanocobalamin, or excipients)
- Leber's disease (due to potential for optic nerve damage with B12 in predisposed individuals)
Drug Interactions
Levodopa
Pyridoxine (Vitamin B6) may reduce the efficacy of levodopa (used in Parkinson's disease), although this interaction is less common with levodopa/carbidopa combinations.
Certain antibiotics (e.g., Chloramphenicol)
May interfere with Cyanocobalamin (Vitamin B12) absorption or utilization.
Isoniazid, Oral Contraceptives, Cycloserine, Hydralazine, Penicillamine
These medications may increase the requirement for Pyridoxine, potentially leading to B6 deficiency.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of sight and reach of children.
Overdose
Since B vitamins are water-soluble, excess amounts are generally excreted in urine. However, very high doses of Pyridoxine (B6) over a prolonged period (e.g., >200 mg/day for months or years) can lead to peripheral neuropathy. Management for overdose is symptomatic and supportive; discontinue the drug and seek medical attention.
Pregnancy & Lactation
Generally considered safe and often recommended as supplements during pregnancy and lactation to meet increased nutritional needs. Folic acid (another B vitamin) is crucial for preventing neural tube defects. Always consult a doctor before taking any medication or supplement during these periods.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the manufacturing date, depending on specific manufacturer and storage conditions.
Availability
Pharmacies, drugstores
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
While specific clinical trials for the Solbion-100 mg branded formulation may not be widely published, the efficacy and safety of its generic components (Thiamine, Pyridoxine, Cyanocobalamin) in treating and preventing vitamin deficiencies are extensively documented and supported by numerous clinical studies over decades.
Lab Monitoring
- Serum levels of B vitamins (if deficiency is suspected, for diagnosis, or for monitoring treatment response)
- Liver and kidney function tests (for baseline and if concerns arise, especially with chronic use of high doses)
Doctor Notes
- Educate patients on the importance of a balanced diet alongside supplementation.
- Monitor for signs of peripheral neuropathy if prescribing high doses of Pyridoxine (B6) for extended periods.
- For suspected B12 deficiency, ensure proper diagnostic workup to differentiate from pernicious anemia or other causes before initiating therapy.
Patient Guidelines
- Take Solbion-100 mg tablet exactly as directed by your doctor or pharmacist.
- Do not exceed the recommended dose without medical advice.
- Inform your doctor about all other medications, herbal products, and supplements you are taking to avoid potential interactions.
- Store the medicine in a cool, dry place, away from direct sunlight and moisture.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Solbion-100 mg tablet is generally not expected to impair your ability to drive or operate machinery. However, if you experience dizziness or any side effects that affect your concentration, you should avoid such activities.
Lifestyle Advice
- Maintain a balanced and nutritious diet rich in fruits, vegetables, whole grains, and lean proteins to support overall vitamin intake.
- Limit or avoid excessive alcohol consumption, as it can impair B vitamin absorption.
- Regular physical activity can improve general health and well-being.
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