Solider
Generic Name
Solifenacin Succinate
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| solider 10 mg tablet | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Solider 10 mg Tablet is used to treat symptoms of overactive bladder, such as frequent urination, urgent need to urinate, and inability to control urination (urge incontinence).
Uses & Indications
Dosage
Adults
Recommended starting dose is 5 mg once daily. May be increased to 10 mg once daily based on response and tolerability.
Elderly
No dose adjustment is generally required, but caution is advised due to potential for increased sensitivity.
Renal_impairment
For severe renal impairment (CrCl < 30 mL/min), maximum dose is 5 mg once daily. Use with caution.
How to Take
Take orally once daily with water, with or without food. Swallow the tablet whole, do not crush or chew.
Mechanism of Action
Solifenacin is a competitive muscarinic receptor antagonist. It selectively blocks M3 muscarinic receptors primarily in the bladder, reducing detrusor muscle contractions and thereby decreasing urinary frequency, urgency, and incontinence.
Pharmacokinetics
Onset
Within a few hours for initial effects; full therapeutic effect typically within 2-4 weeks.
Excretion
Primarily excreted in urine (approximately 69%), with a smaller portion in feces (approximately 23%).
Half life
Approximately 45-68 hours.
Absorption
Well absorbed from the gastrointestinal tract, with absolute bioavailability of about 90%.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4, to several inactive and one active metabolite.
Side Effects
Contraindications
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Severe liver impairment
- Hypersensitivity to solifenacin or any excipients
Drug Interactions
Other anticholinergic agents
May potentiate anticholinergic effects.
CYP3A4 inducers (e.g., rifampicin)
May decrease solifenacin efficacy.
Strong CYP3A4 inhibitors (e.g., ketoconazole)
May increase solifenacin exposure; limit solifenacin dose to 5 mg/day.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe anticholinergic effects like dry mouth, constipation, blurred vision, tachycardia, urinary retention, and drowsiness. Treatment is supportive, and gastric lavage may be considered. Physostigmine may be used in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is not known whether solifenacin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Severe liver impairment
- Hypersensitivity to solifenacin or any excipients
Drug Interactions
Other anticholinergic agents
May potentiate anticholinergic effects.
CYP3A4 inducers (e.g., rifampicin)
May decrease solifenacin efficacy.
Strong CYP3A4 inhibitors (e.g., ketoconazole)
May increase solifenacin exposure; limit solifenacin dose to 5 mg/day.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe anticholinergic effects like dry mouth, constipation, blurred vision, tachycardia, urinary retention, and drowsiness. Treatment is supportive, and gastric lavage may be considered. Physostigmine may be used in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is not known whether solifenacin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Patent expired, generics available
Clinical Trials
Extensive clinical trials have demonstrated solifenacin's efficacy and safety in treating overactive bladder symptoms. Trials have shown significant reduction in urinary urgency, frequency, and incontinence episodes compared to placebo.
Lab Monitoring
- Routine liver and kidney function tests for patients with pre-existing impairment.
Doctor Notes
- Assess patient for bladder outlet obstruction before initiating treatment.
- Monitor for signs of anticholinergic side effects, especially in elderly.
- Educate patient on lifestyle modifications alongside medication.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Report any severe side effects immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time.
Driving Precautions
May cause blurred vision, dizziness, or drowsiness. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Limit caffeine and alcohol intake.
- Maintain a healthy weight.
- Practice bladder training techniques as advised by your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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