Solu-Medrol
Generic Name
Methylprednisolone Sodium Succinate
Manufacturer
Pfizer
Country
USA (originator), Global
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| solu medrol 40 mg injection | ৳ 460.97 | N/A |
Description
Overview of the medicine
Solu-Medrol 40 mg Injection contains methylprednisolone sodium succinate, a synthetic glucocorticoid with potent anti-inflammatory and immunosuppressive properties. It is used to treat a wide variety of conditions.
Uses & Indications
Dosage
Adults
Dosage varies widely based on the disease being treated and patient response. Typically, for acute conditions, 10-250 mg IV/IM, often administered every 6-24 hours. For 40 mg, it is common for moderate to severe inflammatory or allergic conditions. Maintenance dosage should be individualized and gradually tapered.
Elderly
Similar to adults, but use with caution due to increased risk of side effects such as osteoporosis, fluid retention, and hypertension. Start at the lower end of the dosage range.
Renal_impairment
No specific dosage adjustment is usually required for methylprednisolone, as renal excretion of unchanged drug is minor. However, monitor fluid and electrolyte balance carefully.
How to Take
Solu-Medrol 40 mg is typically administered by intramuscular (IM) injection or intravenous (IV) injection (either bolus or infusion). The powder must be reconstituted with the provided diluent or sterile water for injection before use. Administer slowly, especially when given intravenously.
Mechanism of Action
Methylprednisolone binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus. This complex modulates gene expression, leading to the synthesis of anti-inflammatory proteins and inhibition of pro-inflammatory mediators, thereby reducing inflammation and suppressing immune responses.
Pharmacokinetics
Onset
IV: Effects begin within minutes to hours; IM: 1-2 hours for significant effects.
Excretion
Excreted mainly in the urine as inactive metabolites.
Half life
Plasma half-life is approximately 2-4 hours. Biological half-life is 18-36 hours.
Absorption
Rapidly absorbed after intramuscular (IM) or intravenous (IV) administration. Peak plasma concentrations typically occur within 1 hour after IM injection and immediately after IV administration.
Metabolism
Primarily metabolized in the liver by the cytochrome P450 3A4 (CYP3A4) enzyme system.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone, any other corticosteroids, or any component of the formulation
- Administration of live or live-attenuated vaccines when receiving immunosuppressive doses of corticosteroids
Drug Interactions
Anticoagulants (oral)
Corticosteroids may alter the effects of anticoagulants; close monitoring of coagulation parameters is required.
Diuretics (thiazide or loop)
May enhance potassium depletion.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Concomitant use may increase the risk of gastrointestinal ulceration and bleeding.
CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
May decrease methylprednisolone clearance, increasing plasma concentrations and potential for adverse effects.
CYP3A4 inducers (e.g., rifampin, phenobarbital, phenytoin)
May increase methylprednisolone clearance, decreasing plasma concentrations and therapeutic effect.
Storage
Store unreconstituted vials at controlled room temperature (20-25°C or 68-77°F), protected from light. Do not freeze. Reconstituted solution should be used promptly or stored as per manufacturer's instructions.
Overdose
Acute overdose is rare and usually does not lead to life-threatening situations. Chronic overdose, however, can lead to Cushingoid features, muscle weakness, and adrenal suppression. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Infants born to mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism. Methylprednisolone is excreted in breast milk; advise caution and monitor the infant for adverse effects.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone, any other corticosteroids, or any component of the formulation
- Administration of live or live-attenuated vaccines when receiving immunosuppressive doses of corticosteroids
Drug Interactions
Anticoagulants (oral)
Corticosteroids may alter the effects of anticoagulants; close monitoring of coagulation parameters is required.
Diuretics (thiazide or loop)
May enhance potassium depletion.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Concomitant use may increase the risk of gastrointestinal ulceration and bleeding.
CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
May decrease methylprednisolone clearance, increasing plasma concentrations and potential for adverse effects.
CYP3A4 inducers (e.g., rifampin, phenobarbital, phenytoin)
May increase methylprednisolone clearance, decreasing plasma concentrations and therapeutic effect.
Storage
Store unreconstituted vials at controlled room temperature (20-25°C or 68-77°F), protected from light. Do not freeze. Reconstituted solution should be used promptly or stored as per manufacturer's instructions.
Overdose
Acute overdose is rare and usually does not lead to life-threatening situations. Chronic overdose, however, can lead to Cushingoid features, muscle weakness, and adrenal suppression. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Infants born to mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism. Methylprednisolone is excreted in breast milk; advise caution and monitor the infant for adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years for unreconstituted powder. Reconstituted solution generally stable for 48 hours at controlled room temperature, but specific product labeling should be followed.
Availability
Hospitals and licensed pharmacies
Approval Status
FDA approved
Patent Status
Patent expired for generic, brand specific
WHO Essential Medicine
YesClinical Trials
Methylprednisolone, including Solu-Medrol formulations, has been extensively studied in numerous clinical trials across its wide range of indications, supporting its efficacy and safety profile. Ongoing research continues to explore new uses and optimize treatment regimens.
Lab Monitoring
- Blood glucose levels (especially in diabetic patients)
- Serum electrolytes (e.g., potassium)
- Blood pressure
- Bone mineral density (for long-term therapy)
- Growth monitoring in children
- Ophthalmic exams (for long-term therapy)
Doctor Notes
- Crucial to initiate with the lowest effective dose for the shortest possible duration to minimize adverse effects.
- Patients on chronic corticosteroid therapy require careful monitoring for adrenal suppression, bone health, blood glucose, and ophthalmic complications.
- Consider prophylactic measures (e.g., calcium/vitamin D supplementation, bisphosphonates) for patients at high risk of osteoporosis with long-term use.
- Educate patients on the importance of gradual tapering and reporting any signs of infection or adrenal crisis.
Patient Guidelines
- Do not stop this medicine abruptly; doses must be tapered gradually under medical supervision.
- Report any unusual side effects, especially signs of infection, severe mood changes, or severe abdominal pain.
- Avoid exposure to infections, particularly chickenpox or measles, and inform your doctor if exposed.
- Follow any dietary recommendations, such as reduced sodium intake.
- Carry a steroid card, especially if on long-term therapy, to alert healthcare providers.
Missed Dose Advice
If a dose is missed, it should be administered as soon as remembered, unless it is almost time for the next scheduled dose. In that case, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one. Consult a doctor or pharmacist for guidance.
Driving Precautions
Methylprednisolone may cause dizziness, vertigo, or visual disturbances in some patients. Patients should be advised to use caution when driving or operating machinery until they are reasonably certain that Solu-Medrol does not adversely affect their ability to do so.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to counteract bone loss.
- Regular, moderate exercise can help maintain muscle strength and bone density.
- Avoid excessive alcohol consumption and smoking, which can worsen side effects.
- Regular medical check-ups are essential to monitor for potential side effects.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Solu-Medrol Brand
Other medicines available under the same brand name
