Solu-Medrol
Generic Name
Methylprednisolone Sodium Succinate
Manufacturer
Pfizer
Country
USA (originator)
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| solu medrol 500 mg injection | ৳ 2,186.50 | N/A |
Description
Overview of the medicine
Solu-Medrol (methylprednisolone sodium succinate) is a potent synthetic glucocorticoid used for its anti-inflammatory and immunosuppressive properties. It is administered via injection for rapid action in various conditions requiring corticosteroid therapy.
Uses & Indications
Dosage
Adults
Dosage varies widely based on the specific condition being treated, severity, and patient response. For severe acute conditions, doses ranging from 10-500 mg or more per day are common. For pulse therapy in certain autoimmune disorders, doses of 500-1000 mg may be given daily for 3-5 days.
Elderly
Dosage should be individualized, considering age-related decline in hepatic, renal, or cardiac function, and concomitant diseases or other drug therapy.
Renal_impairment
No specific dosage adjustment is generally required for renal impairment, but caution is advised. Methylprednisolone is dialyzable.
How to Take
For intravenous (IV) or intramuscular (IM) injection. The powder must be reconstituted with the provided diluent before administration. IV administration should be given slowly over several minutes, especially for higher doses.
Mechanism of Action
Methylprednisolone works by binding to intracellular glucocorticoid receptors, modulating gene expression. This leads to the suppression of inflammatory mediators (prostaglandins, leukotrienes) and immune responses, reducing inflammation and suppressing the immune system.
Pharmacokinetics
Onset
Anti-inflammatory effects typically within 1 hour after IV administration.
Excretion
Excreted mainly via urine as metabolites.
Half life
Plasma half-life is approximately 2-3 hours; biological half-life is 18-36 hours.
Absorption
Rapidly and completely absorbed after intravenous or intramuscular administration.
Metabolism
Primarily hepatic, mainly by CYP3A4.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
- Administration of live or live attenuated vaccines in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
Anticoagulants (e.g., warfarin)
Concurrent use may alter the anticoagulant effect; monitor INR closely.
NSAIDs (e.g., ibuprofen, aspirin)
Increased risk of gastrointestinal ulceration and bleeding.
Diuretics (e.g., furosemide, thiazides)
May enhance potassium depletion.
CYP3A4 Inducers (e.g., rifampin, phenytoin)
May increase methylprednisolone metabolism, decreasing its plasma concentrations and effects.
Antidiabetics (e.g., insulin, oral hypoglycemics)
Corticosteroids may increase blood glucose levels, requiring adjustment of antidiabetic medication.
CYP3A4 Inhibitors (e.g., ketoconazole, clarithromycin)
May decrease methylprednisolone metabolism, increasing its plasma concentrations and effects.
Storage
Store unopened vials at controlled room temperature (20-25°C), protected from light. Do not freeze. Reconstituted solution may be stored at refrigerated temperatures (2-8°C) for up to 48 hours.
Overdose
Acute overdose with corticosteroids is rare and usually does not lead to life-threatening situations. Treatment is symptomatic and supportive. No specific antidote is available.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Methylprednisolone is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
- Administration of live or live attenuated vaccines in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
Anticoagulants (e.g., warfarin)
Concurrent use may alter the anticoagulant effect; monitor INR closely.
NSAIDs (e.g., ibuprofen, aspirin)
Increased risk of gastrointestinal ulceration and bleeding.
Diuretics (e.g., furosemide, thiazides)
May enhance potassium depletion.
CYP3A4 Inducers (e.g., rifampin, phenytoin)
May increase methylprednisolone metabolism, decreasing its plasma concentrations and effects.
Antidiabetics (e.g., insulin, oral hypoglycemics)
Corticosteroids may increase blood glucose levels, requiring adjustment of antidiabetic medication.
CYP3A4 Inhibitors (e.g., ketoconazole, clarithromycin)
May decrease methylprednisolone metabolism, increasing its plasma concentrations and effects.
Storage
Store unopened vials at controlled room temperature (20-25°C), protected from light. Do not freeze. Reconstituted solution may be stored at refrigerated temperatures (2-8°C) for up to 48 hours.
Overdose
Acute overdose with corticosteroids is rare and usually does not lead to life-threatening situations. Treatment is symptomatic and supportive. No specific antidote is available.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Methylprednisolone is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years for unopened vials. Reconstituted solution should be used within 48 hours if refrigerated, or within a shorter period at room temperature, as per manufacturer's guidelines.
Availability
Available in hospitals and retail pharmacies
Approval Status
FDA Approved, DGDA Approved
Patent Status
Off-patent, generic versions available
WHO Essential Medicine
YesClinical Trials
Methylprednisolone has undergone extensive clinical trials over decades, establishing its efficacy and safety profile for numerous indications. Ongoing research continues to explore new applications and refine existing treatment protocols.
Lab Monitoring
- Blood glucose levels
- Electrolyte balance (especially potassium)
- Blood pressure monitoring
- Bone mineral density (with long-term use)
- Ophthalmic examinations (for cataracts/glaucoma with long-term use)
- Growth monitoring in pediatric patients
Doctor Notes
- Emphasize gradual tapering of dosage to prevent adrenal insufficiency, especially after prolonged therapy.
- Monitor patients for signs of infection, as corticosteroids can mask symptoms and increase susceptibility.
- Regularly assess for bone mineral density, blood pressure, blood glucose, and ophthalmic changes during long-term treatment.
- Advise patients on appropriate diet (e.g., calcium/Vit D supplementation) and lifestyle modifications.
Patient Guidelines
- Do not stop this medication abruptly, especially after prolonged use, as it can lead to withdrawal symptoms and adrenal insufficiency. Follow your doctor's instructions for tapering the dose.
- Report any unusual side effects or worsening of your condition to your doctor.
- Avoid exposure to people with infections (e.g., chickenpox, measles) while on this medication, as your immune system may be suppressed.
- Carry an identification card stating that you are on corticosteroid therapy.
Missed Dose Advice
Since this is an injection administered by a healthcare professional, a missed dose is unlikely. If a scheduled dose is missed, contact your doctor or healthcare provider immediately to reschedule.
Driving Precautions
This medicine may cause dizziness or visual disturbances in some patients. If you experience these effects, avoid driving or operating machinery until you know how Solu-Medrol affects you.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to support bone health.
- Engage in regular, moderate exercise to help maintain muscle strength and bone density.
- Avoid excessive alcohol consumption.
- Manage stress effectively.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Solu-Medrol Brand
Other medicines available under the same brand name
