Somazin
Generic Name
Citicoline
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| somazin 500 mg injection | ৳ 140.00 | N/A |
Description
Overview of the medicine
Somazin 500 mg Injection contains Citicoline, a psychostimulant and nootropic. It helps in the recovery of brain function and repair of damaged brain cells following various neurological conditions such as stroke, head injury, and cognitive impairment.
Uses & Indications
Dosage
Adults
Acute Ischemic Stroke: 500-1000 mg IV/IM once or twice daily for 6 weeks. Head Trauma: 500-1000 mg IV/IM twice daily for 2-4 weeks. Cognitive Impairment: 500 mg IV/IM once daily.
Elderly
No specific dose adjustment is generally required, but caution is advised, and dose may be adjusted based on clinical response.
Renal_impairment
No specific dose adjustment is typically required, as it is primarily metabolized in the liver.
How to Take
Administer intramuscularly (IM) or intravenously (IV). For IV administration, it can be given as a slow intravenous injection (over 3-5 minutes) or as an intravenous drip (over 40-60 minutes).
Mechanism of Action
Citicoline enhances the synthesis of phosphatidylcholine, a major component of neuronal membranes. It also increases levels of neurotransmitters like acetylcholine and dopamine in the brain, improving neuronal function, cerebral blood flow, and reducing oxidative stress.
Pharmacokinetics
Onset
Within hours for some effects, but clinical improvement typically observed over days to weeks.
Excretion
Excreted primarily as carbon dioxide via respiration and as choline and cytidine via urine.
Half life
Biphasic half-life with an initial rapid phase (hours) and a slower elimination phase (days).
Absorption
Well absorbed after oral, intramuscular, and intravenous administration. Bioavailability is high.
Metabolism
Metabolized in the liver to choline and cytidine.
Side Effects
Contraindications
- Hypersensitivity to Citicoline or any excipients
- Patients with hypertonia of the parasympathetic nervous system
Drug Interactions
Levodopa
Citicoline may potentiate the effects of levodopa. If co-administered, monitor for increased dopaminergic effects.
Meclofenoxate (Centrophenoxine)
Avoid co-administration due to potential additive central stimulatory effects.
Storage
Store below 30°C, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
No specific antidote. Management is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed and potential benefits outweigh risks. Caution advised during lactation as it is unknown if Citicoline is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to Citicoline or any excipients
- Patients with hypertonia of the parasympathetic nervous system
Drug Interactions
Levodopa
Citicoline may potentiate the effects of levodopa. If co-administered, monitor for increased dopaminergic effects.
Meclofenoxate (Centrophenoxine)
Avoid co-administration due to potential additive central stimulatory effects.
Storage
Store below 30°C, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
No specific antidote. Management is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed and potential benefits outweigh risks. Caution advised during lactation as it is unknown if Citicoline is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date when stored under recommended conditions.
Availability
Hospitals, pharmacies
Approval Status
Approved in many countries globally
Patent Status
Generic available, original patent expired
Clinical Trials
Numerous clinical trials have investigated Citicoline's efficacy in stroke, traumatic brain injury, and cognitive disorders, showing mixed but generally positive results for neuroprotection and functional recovery.
Lab Monitoring
- No routine lab monitoring is generally required. Monitor clinical neurological status.
Doctor Notes
- Citicoline is a valuable adjuvant in neurological recovery.
- Consider the patient's overall clinical picture and co-morbidities.
- Educate patients on the duration of therapy and realistic expectations.
Patient Guidelines
- Report any unusual side effects to your doctor.
- Do not stop the medication without consulting your doctor.
- Store according to instructions.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose.
Driving Precautions
Citicoline can cause dizziness or vision disturbances in some patients. Advise caution when driving or operating machinery until the effects are known.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid smoking and excessive alcohol consumption.
- Engage in cognitive stimulating activities.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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