Somazin
Generic Name
Citicoline
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| somazin 500 mg tablet | ৳ 50.00 | ৳ 500.00 |
Description
Overview of the medicine
Citicoline is an endogenous compound that serves as an intermediate in the biosynthesis of phosphatidylcholine, a major component of neuronal cell membranes. It is used in conditions of cerebral insufficiency, such as stroke, head injury, and other neurological disorders to support brain function and repair.
Uses & Indications
Dosage
Adults
Oral: 500 mg to 2000 mg daily, usually divided into 2-3 doses. Dosage depends on the severity of the condition.
Elderly
No specific dose adjustment is generally required for elderly patients.
Renal_impairment
No specific dose adjustment is considered necessary in patients with renal impairment.
How to Take
Somazin-500 mg tablet should be taken orally, with or without food. It can be swallowed whole with water.
Mechanism of Action
Citicoline acts as a precursor for phosphatidylcholine synthesis, which is crucial for neuronal membrane integrity and repair. It enhances the synthesis of acetylcholine and other neurotransmitters, increases cerebral blood flow, and improves cerebral metabolism. It also reduces fatty acid accumulation after ischemic stroke.
Pharmacokinetics
Onset
Variable, noticeable effects may take hours to days depending on the condition.
Excretion
Primarily excreted as carbon dioxide (CO2) via the lungs and also via urine in smaller amounts.
Half life
Biphasic elimination. Main metabolites (choline, cytidine) have different half-lives (e.g., choline ~1.5 hours, cytidine ~6.5 hours).
Absorption
Rapidly absorbed after oral administration, bioavailability is high (approximately 90%).
Metabolism
Hydrolyzed in the gut wall and liver to its primary metabolites, choline and cytidine.
Side Effects
Contraindications
- Known hypersensitivity to Citicoline or any of its components
- Hypertonia of the parasympathetic nervous system
Drug Interactions
Levodopa (L-Dopa)
Citicoline may enhance the effects of Levodopa. Concomitant use should be monitored.
Meclofenoxate (Centrophenoxine)
Avoid concurrent use with medications containing Meclofenoxate.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Citicoline has a low toxicity profile. In case of accidental overdose, symptomatic and supportive treatment should be initiated. No specific antidote is known.
Pregnancy & Lactation
Pregnancy Category B. Limited data are available on Citicoline use during pregnancy and lactation. It should be used only if clearly needed and the potential benefits outweigh the potential risks. Consult your doctor.
Side Effects
Contraindications
- Known hypersensitivity to Citicoline or any of its components
- Hypertonia of the parasympathetic nervous system
Drug Interactions
Levodopa (L-Dopa)
Citicoline may enhance the effects of Levodopa. Concomitant use should be monitored.
Meclofenoxate (Centrophenoxine)
Avoid concurrent use with medications containing Meclofenoxate.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Citicoline has a low toxicity profile. In case of accidental overdose, symptomatic and supportive treatment should be initiated. No specific antidote is known.
Pregnancy & Lactation
Pregnancy Category B. Limited data are available on Citicoline use during pregnancy and lactation. It should be used only if clearly needed and the potential benefits outweigh the potential risks. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 24 to 36 months from the date of manufacture, when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved in Bangladesh
Patent Status
Generic available
Clinical Trials
Citicoline has been studied in numerous clinical trials for its efficacy in stroke, head injury, and other neurological conditions, showing positive outcomes in cognitive and functional recovery for various patient groups.
Lab Monitoring
- Routine laboratory monitoring is not typically required for patients taking Citicoline.
Doctor Notes
- Citicoline can be a valuable adjunct in the management of acute and chronic cerebral pathologies.
- Monitor patient's cognitive and neurological status periodically.
- Educate patients on potential mild side effects and drug interactions, especially with Levodopa.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any unusual or severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Citicoline is generally considered safe for driving or operating machinery. However, if you experience dizziness or any other side effects that could impair your ability, avoid such activities.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Engage in regular physical activity.
- Incorporate cognitive exercises or mentally stimulating activities.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
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