Sporin
Generic Name
Cephalexin 125 mg Pediatric Drop
Manufacturer
Generic Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sporin 125 mg pediatric drop | ৳ 60.00 | N/A |
Description
Overview of the medicine
Sporin 125 mg Pediatric Drop is an antibiotic medication belonging to the cephalosporin class, primarily used to treat various bacterial infections in children.
Uses & Indications
Dosage
Adults
Not typically used for adults in pediatric drop formulation; adult dosage for oral Cephalexin is typically 250-500 mg every 6 hours.
Elderly
Adjusted for renal function. Similar to adult dosage but with caution.
Renal_impairment
Dosage adjustment required based on creatinine clearance (e.g., reduced dose or increased dosing interval).
How to Take
Administer orally. Shake the bottle well before each use. Can be given with or without food. Use a calibrated dropper or measuring spoon provided with the medicine.
Mechanism of Action
Cephalexin is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Typically within 1 hour
Excretion
Primarily via renal excretion (glomerular filtration and tubular secretion); about 80% of the dose is excreted unchanged in urine within 8 hours.
Half life
Approximately 0.5 to 1.2 hours in adults with normal renal function; longer in neonates and with renal impairment.
Absorption
Rapidly and well absorbed from the gastrointestinal tract; peak plasma concentrations achieved within 1 hour.
Metabolism
Not significantly metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cephalexin or other cephalosporins.
- History of severe hypersensitivity (e.g., anaphylaxis) to penicillin.
Drug Interactions
Metformin
Cephalexin may increase metformin concentrations, potentially requiring dose adjustment of metformin.
Probenecid
Concomitant administration of probenecid may increase and prolong serum concentrations of cephalexin.
Oral Contraceptives
Some antibiotics, including cephalexin, may reduce the effectiveness of oral contraceptives, though evidence is limited.
Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect, requiring closer monitoring of INR.
Storage
Store dry powder at room temperature (below 30°C). After reconstitution, store in a refrigerator (2-8°C) and discard after 7-14 days depending on manufacturer instructions. Do not freeze.
Overdose
Symptoms may include nausea, vomiting, epigastric distress, diarrhea, and hematuria. Management involves symptomatic and supportive treatment; hemodialysis may be useful in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Cephalexin is excreted in human milk in low concentrations; use with caution during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to cephalexin or other cephalosporins.
- History of severe hypersensitivity (e.g., anaphylaxis) to penicillin.
Drug Interactions
Metformin
Cephalexin may increase metformin concentrations, potentially requiring dose adjustment of metformin.
Probenecid
Concomitant administration of probenecid may increase and prolong serum concentrations of cephalexin.
Oral Contraceptives
Some antibiotics, including cephalexin, may reduce the effectiveness of oral contraceptives, though evidence is limited.
Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect, requiring closer monitoring of INR.
Storage
Store dry powder at room temperature (below 30°C). After reconstitution, store in a refrigerator (2-8°C) and discard after 7-14 days depending on manufacturer instructions. Do not freeze.
Overdose
Symptoms may include nausea, vomiting, epigastric distress, diarrhea, and hematuria. Management involves symptomatic and supportive treatment; hemodialysis may be useful in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Cephalexin is excreted in human milk in low concentrations; use with caution during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 years for dry powder; 7-14 days after reconstitution when stored as directed.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent (generic available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of cephalexin for various bacterial infections in pediatric and adult populations.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) in patients with impaired renal function.
- Complete blood count (CBC) if prolonged therapy is anticipated or in patients predisposed to blood dyscrasias.
Doctor Notes
- Confirm bacterial etiology before prescribing to prevent antibiotic resistance.
- Counsel parents on the importance of completing the full course and proper storage of the reconstituted suspension.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Do not share this medication with others.
- Shake the oral suspension well before each use.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Cephalexin is generally not expected to impair the ability to drive or operate machinery. However, if side effects like dizziness or headache occur, avoid driving until you feel well.
Lifestyle Advice
- Maintain good hydration, especially if experiencing diarrhea.
- Avoid alcohol during treatment, as it may worsen gastrointestinal side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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